Inclusion Criteria:

- Histologically confirmed brain tumors (glioblastoma multiforme, anaplastic
astrocytoma, medullo

- Age 0 through 17 years (pediatric subjects), and 18 years and above (adult subjects)

- Lansky score of ≥ 60 (0-15 years) or Karnofsky (16 years or older) performance score
of ≥ 60%

- Adequate organ function within 14 days of study registration including the following:

- Adequate bone marrow reserve: absolute neutrophil (segmented and bands) count
(ANC) ≥ 1.0 x 10^9/L, platelets ≥100 x 10^9/L; hemoglobin ≥ 8 g/dL

- Hepatic: bilirubin ≤1.3 mg/dL or 0-22 mmol/L, aspartate transaminase (AST) and
alanine transaminase (ALT) < 3 x upper limit of normal (ULN)

- Renal: Normal serum creatinine for age (below) or creatinine clearance >60
ml/min/1.73 m^2.

- Sexually active women of child bearing potential must agree to use adequate
contraception (diaphragm, birth control pills, injections, intrauterine device [IUD],
surgical sterilization, subcutaneous implants, or abstinence, etc.) for the duration
of the vaccination period. Sexually active men must agree to use barrier
contraceptive for the duration of the vaccination period.

- Willingness to travel to participate in study if from outside local region.

- Voluntary written informed consent must be obtained from all patients (if of assent
age) and their parents or legal guardians before performance of any study-related
procedure not part of normal medical care, with the understanding that consent may be
withdrawn by the subject at any time without prejudice to future medical care.

Exclusion criteria:

- Pregnant or breast-feeding. Pregnancy testing will be performed on all menstruating
females within 14 days of study enrollment.

- Uncontrolled intercurrent illness including, but not limited to ongoing or active
infection, symptomatic congestive heart failure, unstable angina pectoris, or
psychiatric illness/social situations that would limit compliance with study
requirements.

- Currently receiving any other investigational agents.

- History of immune system abnormalities such as hyperimmunity (e.g., autoimmune
diseases) and hypoimmunity (e.g., myelodysplastic disorders, marrow failures, AIDS,
ongoing pregnancy, transplant immuno-suppression).

- Any conditions that could potentially alter immune function (e.g., AIDS, multiple
sclerosis, diabetes, renal failure).