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GOG-0262: A Phase III Trial of Every-3-Weeks Paclitaxel Versus Dose Dense Weekly Paclitaxel in Combination With Carboplatin With or Without Concurrent and Consolidation Bevacizumab (NSC #704865, IND #113912) in the Treatment of Primary Stage II, III or IV Epithelial Ovarian, Peritoneal or Fallopian Tube Cancer and ACRIN 6695: Perfusion CT Imaging to Evaluate Treatment Response in Patients Participating in GOG-0262

Phase 3
18 Years
Open (Enrolling)
Brenner Tumor, Ovarian Clear Cell Cystadenocarcinoma, Ovarian Endometrioid Adenocarcinoma, Ovarian Mixed Epithelial Carcinoma, Ovarian Mucinous Cystadenocarcinoma, Ovarian Serous Cystadenocarcinoma, Ovarian Undifferentiated Adenocarcinoma, Stage IIA Fallopian Tube Cancer, Stage IIA Ovarian Epithelial Cancer, Stage IIA Primary Peritoneal Cavity Cancer, Stage IIB Fallopian Tube Cancer, Stage IIB Ovarian Epithelial Cancer, Stage IIB Primary Peritoneal Cavity Cancer, Stage IIC Fallopian Tube Cancer, Stage IIC Ovarian Epithelial Cancer, Stage IIC Primary Peritoneal Cavity Cancer, Stage IIIA Fallopian Tube Cancer, Stage IIIA Ovarian Epithelial Cancer, Stage IIIA Primary Peritoneal Cavity Cancer, Stage IIIB Fallopian Tube Cancer, Stage IIIB Ovarian Epithelial Cancer, Stage IIIB Primary Peritoneal Cavity Cancer, Stage IIIC Fallopian Tube Cancer, Stage IIIC Ovarian Epithelial Cancer, Stage IIIC Primary Peritoneal Cavity Cancer, Stage IV Fallopian Tube Cancer, Stage IV Ovarian Epithelial Cancer, Stage IV Primary Peritoneal Cavity Cancer

Thank you

Trial Information

GOG-0262: A Phase III Trial of Every-3-Weeks Paclitaxel Versus Dose Dense Weekly Paclitaxel in Combination With Carboplatin With or Without Concurrent and Consolidation Bevacizumab (NSC #704865, IND #113912) in the Treatment of Primary Stage II, III or IV Epithelial Ovarian, Peritoneal or Fallopian Tube Cancer and ACRIN 6695: Perfusion CT Imaging to Evaluate Treatment Response in Patients Participating in GOG-0262


I. To determine if the weekly paclitaxel regimen increases the time until first progression
or death (progression-free survival [PFS]) compared to the every-3-week paclitaxel regimen
in patients with stage II, III or IV ovarian epithelial, primary peritoneal, or fallopian
tube cancer who are receiving carboplatin with or without bevacizumab.


I. To determine if the weekly paclitaxel increases the duration of overall survival compared
to the every-3-week paclitaxel when combined with carboplatin with or without bevacizumab.

II. To compare the weekly paclitaxel to the every-3-week paclitaxel with respect to the
incidence of severe or serious adverse events when it is combined with carboplatin with or
without bevacizumab.

III. To compare the weekly paclitaxel to the every-3-week paclitaxel with respect to
patients' self-reported quality of life (QOL) as measured by the FACT-O-TOI, when paclitaxel
is combined with carboplatin with or without bevacizumab (as of 02/08/2012, the QOL portion
of this study is complete; patients enrolled after this date will not have QOL assessments).


I. To evaluate single nucleotide polymorphisms associated with PFS and toxicity in
advanced-stage ovarian epithelial, primary peritoneal, and fallopian tube cancer using
genome-wide association studies.* II. To evaluate genomic signatures in tumor tissues that
are predictive for patient survival in advanced-stage ovarian epithelial, primary
peritoneal, and fallopian tube cancer.* III. To evaluate the association between serum and
plasma biomarkers and response to antiangiogenesis therapy in advanced-stage ovarian
epithelial, primary peritoneal, and fallopian tube cancer.*

NOTE: *As of 02/08/2012, the translational research (TR) portion of this study is complete;
patients enrolled after this date will not have TR specimens collected.


I. To determine whether larger changes in the tumor perfusion parameters from baseline
timepoint (T0) to early-therapy T2 are prognostic of higher PFS rate at 6 months (PFS-6)
from enrollment in patients treated with weekly or every-3-week paclitaxel regimens, who are
receiving carboplatin with or without bevacizumab.***


I. To determine whether larger changes in tumor perfusion parameters from baseline T0 to
intermediate T1 and from T1 to T2 are prognostic of higher PFS-6 in patients treated with
weekly or every-3-week paclitaxel regimens, who are receiving carboplatin with or without
bevacizumab.*** II. To determine whether larger changes in tumor perfusion parameters values
from T0 to T1, T0 to T2, and T1 to T2 are prognostic of better overall survival in all
treatment arms.*** III. To assess the association between changes in tumor perfusion
parameters before and after chemotherapy initiation (T0 to T1) and subsequent best tumor
response according to standard anatomic Response Evaluation Criteria in Solid Tumors
(RECIST).*** IV. To assess the association between tumor perfusion parameters before
chemotherapy and subsequent best tumor response according to RECIST, PFS-6, and overall
survival.*** V. To test the assumption that tumor perfusion parameters are reliable,
user-independent, and reproducible parameters of tumor microvascular characteristics; a
subgroup of 15 patients will have repeat computed tomography (CT) perfusion studies at the
intermediate T1.***

NOTE: ***Patients enrolled after February 8, 2012 must participate in the ACRIN 6695
component at ACRIN-qualified institutions.

OUTLINE: This is a multicenter study. Patients are stratified according to disease stage (II
vs III vs IV), performance status (0 vs 1-2), inclusion of bevacizumab in the treatment
regimen (yes vs no), and decision to use neoadjuvant chemotherapy (yes vs no). Patients are
randomized to 1 of 2 treatment arms (beginning on 04-30-2012, the trial is no longer
randomized and the chemotherapy regimen is selected and declared prior to enrolling in the

ARM I: Patients receive paclitaxel IV over 3 hours and carboplatin IV over 30 minutes on day
1. Treatment repeats every 21 days for 6 courses.

ARM II: Patients receive paclitaxel IV over 1 hour on days 1, 8, and 15 and carboplatin IV
over 30 minutes on day 1. Treatment repeats every 21 days for 6 courses.

Patients in both arms may receive optional** bevacizumab IV over 30-90 minutes on day 1
beginning in course 2. Courses of bevacizumab repeat every 21 days in the absence of disease
progression or unacceptable toxicity.

NOTE: **Before enrolling onto this study, each patient chooses whether the study treatment
will include concurrent and maintenance bevacizumab.

After completion of study treatment, patients are followed up every 3 months for 2 years,
every 6 months for 3 years, and then annually thereafter.

Inclusion Criteria:

- Patients must have measurable disease; at least one target lesion must have a minimum
length of 1 cm in both the long and short axis (determined at the local site); for
primary surgery patients, if no radiographic evidence of measurable disease is
obtained prior to registration this can be based on surgical findings; imaging then
would need to be completed in the 14 days between Gynecology Oncology Group (GOG)
registration and chemotherapy initiation

- Histologically confirmed ovarian epithelial, primary peritoneal, or fallopian tube

- Stage II -IV suboptimally debulked (any residual disease > 1 cm); International
Federation of Gynecology and Obstetrics (FIGO) stage is assessed following the
completion of initial abdominal surgery, appropriate imaging studies and with
appropriate tissue available for histologic evaluation; the minimum surgery
required is an abdominal surgery providing tissue for histologic evaluation and
establishing and documenting the primary site and stage; if additional surgery
was performed, it should have been in accordance with appropriate surgery for
ovarian or peritoneal carcinoma described in the GOG Surgical Procedures Manual

- The following histologic epithelial cell types are eligible:

- Serous

- Endometrioid

- Clear cell

- Mucinous adenocarcinoma

- Undifferentiated carcinoma

- Mixed epithelial carcinoma

- Transitional cell carcinoma

- Malignant Brenner tumor

- Adenocarcinoma not otherwise specified

- Histologic features of the tumor must be compatible with a primary Müllerian
epithelial adenocarcinoma; patients may have co-existing fallopian tube carcinoma
in-situ so long as the primary origin of invasive tumor is ovarian, peritoneal or
fallopian tube; of note, patients with clear cell and mucinous tumors will be
eligible unless there is a higher priority protocol

- For patients undergoing neoadjuvant chemotherapy (NAC) with interval cytoreductive
surgery (ICS), a core tissue (not fine needle aspiration) biopsy is required; the
tissue must be consistent with a müllerian origin; patients will require
documentation of at least stage II or extraovarian sites of disease acquired via
imaging or surgery (without attempt at cytoreduction)

- Patients will not be eligible for therapy on other clinical trials evaluating
consolidation or maintenance therapy

- Absolute neutrophil count (ANC) >= 1,500/mm^3 (not induced or supported by
granulocyte colony-stimulating factors)

- Platelet count >= 100,000/mm^3

- Creatinine =< 1.5 times upper limit of normal (ULN)

- Bilirubin =< 1.5 times ULN

- Serum glutamic oxalo-acetic transaminase (SGOT) =< 3 times ULN

- Alkaline phosphatase =< 2.5 times ULN

- Neuropathy (sensory or motor) >= Common Terminology Criteria for Adverse Events
(CTCAE) grade 1

- GOG performance status 0-2

- Patients must be entered within 12 weeks of diagnostic/staging surgery

- An approved informed consent and authorization permitting release of personal health
information and must be signed by the patient or guardian

- Patients who elect to receive bevacizumab must meet the following criteria:

- Patients in this trial may receive ovarian estrogen and/or progestin replacement
therapy as indicated at the lowest effective dose(s) for control of menopausal
symptoms at any time, but not high-dose progestins for management of anorexia
while on protocol-directed therapy or prior to disease progression due to
thrombophlebitis risk

- Prothrombin time (PT) such that international normalized ratio (INR) is =< 1.5
(or an in-range INR, usually between 2 and 3, if a patient is on a stable dose
of therapeutic warfarin for management of venous thrombosis including pulmonary

- Heparin, lovenox or alternative anticoagulants are acceptable

- Partial prothrombin time (PTT) < 1.2 times ULN

- American College of Radiology Imaging Network (ACRIN) 6695 imaging study:

- Patients enrolled after February 8, 2012 must participate in the ACRIN 6695
component at ACRIN-qualified institutions

- At least one target lesion must have a minimum length of 1 cm in both the long
and short axis (as determined by the local site), at least half of the target
lesion must have attenuation greater than or equal to 10 Hounsfield Units (HU)
on the unenhanced (computed tomography (CT), and at least half of the lesion
must have maximum enhancement greater than or equal to 5 HU in the perfusion CT
scan (as determined by the American College of Radiology [ACR] Imaging Core Lab)

Exclusion Criteria:

- Patients with a current diagnosis of borderline epithelial ovarian tumor (formerly
"tumors of low malignant potential") or recurrent invasive epithelial ovarian,
primary peritoneal or fallopian tube cancer treated with surgery only (such as
patients with stage I-A or I-B low grade epithelial ovarian or fallopian tube
cancers) are not eligible; patients with a prior diagnosis of a borderline tumor that
was surgically resected and who subsequently develop an unrelated, new invasive
epithelial ovarian, peritoneal primary or fallopian tube cancer are eligible,
provided that they have not received prior chemotherapy for any ovarian tumor

- Synchronous primary endometrial cancer or a history of primary endometrial cancer,
unless all of the following conditions are met:

- Stage not greater than Ia

- Grade 1 or 2

- No more than superficial myometrial invasion

- No vascular or lymphatic invasion

- No poorly differentiated subtypes, including papillary serous, clear cell, or
other FIGO grade 3 lesions

- Prior radiotherapy to any portion of the abdominal cavity or pelvis

- Prior radiotherapy for localized cancer of the breast, head and neck, or skin is
allowed provided that it was completed > 3 years ago and that the patient
remains free of recurrent or metastatic disease

- Prior chemotherapy for any abdominal or pelvic tumor, including neoadjuvant
chemotherapy for ovarian, primary peritoneal, or fallopian tube cancer

- Prior adjuvant chemotherapy for localized breast cancer allowed provided that it
was completed > 3 years ago and that the patient remains free of recurrent or
metastatic disease

- Prior targeted therapy (including, but not limited to, vaccines, antibodies, tyrosine
kinase inhibitors) or hormonal therapy for management of ovarian epithelial,
fallopian tube, or primary peritoneal cancer

- Prior therapy with any anti-vascular endothelial growth factor (VEGF) drug, including

- Acute hepatitis or active infection that requires parenteral antibiotics

- Patients who are pregnant or nursing

- Patients of childbearing potential must agree to use contraceptive measures during
study therapy and for at least six months after completion of bevacizumab therapy

- With the exception of non-melanoma skin cancer, patients with other invasive
malignancies who had (or have) any evidence of the other cancer present within the
last five years or whose previous cancer treatment contraindicates this protocol

- Clinically significant cardiovascular disease, including:

- Myocardial infarction or unstable angina within the past 6 months

- New York Heart Association (NYHA) class II or greater congestive heart failure

- Serious cardiac arrhythmia requiring medication (this does not include
asymptomatic, atrial fibrillation with controlled ventricular rate)

- Patients with medical history or conditions not otherwise previously specified which
in the opinion of the investigator should exclude participation in this study

- Patients with known allergy to cremophor or polysorbate 80

- Exclusions for patients who elect to receive bevacizumab:

- * Patients with serious non-healing wound, ulcer, or bone fracture; this includes
history of abdominal fistula, gastrointestinal perforation or intra-abdominal abscess
within 28 days; patients with granulating incisions healing by secondary intention
with no evidence of fascial dehiscence or infection are eligible but require weekly
wound examinations

- * Patients with active bleeding or pathologic conditions that carry high risk of
bleeding, such as known bleeding disorder, coagulopathy, or tumor involving major

- * Patients with history or evidence upon physical examination of central nervous
system (CNS) disease, including primary brain tumor, seizures not controlled with
standard medical therapy, any brain metastases, or history of cerebrovascular
accident (CVA, stroke), transient ischemic attack (TIA) or subarachnoid hemorrhage
within six months of the first date of treatment on this study

- Patients with CTCAE Grade 2 or greater peripheral vascular disease [at least
brief (< 24 hours) episodes of ischemia managed non-surgically and without
permanent deficit]

- Patients with a history of CVA within six months

- * Patients with known hypersensitivity to Chinese hamster ovary cell products or
other recombinant human or humanized antibodies

- * Patients with clinically significant proteinuria; patients must have a urine
protein-creatinine ratio (UPCR) < 1.0 to allow participation in the study

- * Patients with or with anticipation of invasive procedures as defined below:

- Major surgical procedure, open biopsy or significant traumatic injury within 28
days prior to the first date of bevacizumab therapy (cycle 2)

- Major surgical procedure anticipated during the course of the study; this
includes, but is not limited to, abdominal surgery (laparotomy or laparoscopy)
prior to disease progression, such as colostomy or enterostomy reversal,
secondary cytoreductive surgery, or second look surgery

- Any tissue biopsy, such as a core biopsy, within 7 days prior to the first date
of bevacizumab therapy (cycle 2)

- * Patients with clinical symptoms or signs of gastrointestinal obstruction AND who
require parenteral hydration and/or nutrition

- * Patients with metastatic tumor in the parenchyma of the liver or lungs with
proximity to large vessels which could make the patients at high risk of lethal
hemorrhage during treatment with bevacizumab (ie. hemoptysis, liver rupture)

- ACRIN 6695 exclusions:

- Patients with contraindication to iodinated contrast for perfusion CT imaging

- Patients who receive metformin within 48 hours before perfusion CT imaging

Type of Study:


Study Design:

Allocation: Non-Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Outcome Measure:

Progression-free survival

Outcome Time Frame:

Time from study entry to time of progression or death, whichever occurs first, assessed up to 2 years

Safety Issue:


Principal Investigator

John Chan

Investigator Role:

Principal Investigator

Investigator Affiliation:

Gynecologic Oncology Group


United States: Food and Drug Administration

Study ID:




Start Date:

September 2010

Completion Date:

Related Keywords:

  • Brenner Tumor
  • Ovarian Clear Cell Cystadenocarcinoma
  • Ovarian Endometrioid Adenocarcinoma
  • Ovarian Mixed Epithelial Carcinoma
  • Ovarian Mucinous Cystadenocarcinoma
  • Ovarian Serous Cystadenocarcinoma
  • Ovarian Undifferentiated Adenocarcinoma
  • Stage IIA Fallopian Tube Cancer
  • Stage IIA Ovarian Epithelial Cancer
  • Stage IIA Primary Peritoneal Cavity Cancer
  • Stage IIB Fallopian Tube Cancer
  • Stage IIB Ovarian Epithelial Cancer
  • Stage IIB Primary Peritoneal Cavity Cancer
  • Stage IIC Fallopian Tube Cancer
  • Stage IIC Ovarian Epithelial Cancer
  • Stage IIC Primary Peritoneal Cavity Cancer
  • Stage IIIA Fallopian Tube Cancer
  • Stage IIIA Ovarian Epithelial Cancer
  • Stage IIIA Primary Peritoneal Cavity Cancer
  • Stage IIIB Fallopian Tube Cancer
  • Stage IIIB Ovarian Epithelial Cancer
  • Stage IIIB Primary Peritoneal Cavity Cancer
  • Stage IIIC Fallopian Tube Cancer
  • Stage IIIC Ovarian Epithelial Cancer
  • Stage IIIC Primary Peritoneal Cavity Cancer
  • Stage IV Fallopian Tube Cancer
  • Stage IV Ovarian Epithelial Cancer
  • Stage IV Primary Peritoneal Cavity Cancer
  • Adenocarcinoma
  • Adenocarcinoma, Mucinous
  • Brenner Tumor
  • Carcinoma
  • Cystadenocarcinoma
  • Peritoneal Neoplasms
  • Fallopian Tube Neoplasms
  • Carcinoma, Endometrioid
  • Cystadenocarcinoma, Mucinous
  • Cystadenocarcinoma, Serous
  • Neoplasms, Glandular and Epithelial
  • Ovarian Neoplasms



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University of Texas Southwestern Medical CenterDallas, Texas  
University of KentuckyLexington, Kentucky  40536-0098
Montana Cancer Consortium CCOPBillings, Montana  59101
Alegent Health Immanuel Medical CenterOmaha, Nebraska  68122
Alegent Health Bergan Mercy Medical CenterOmaha, Nebraska  68124
Northwest HospitalSeattle, Washington  98133
Virginia Mason CCOPSeattle, Washington  98101
Huntsman Cancer Institute/University of UtahSalt Lake City, Utah  84112
Metro-Minnesota CCOPSt. Louis Park, Minnesota  
UC Davis Comprehensive Cancer CenterSacramento, California  95817
Providence HospitalSouthfield, Michigan  48075
Tufts Medical CenterBoston, Massachusetts  02111
Lakeview HospitalStillwater, Minnesota  55082
Oregon Health and Science UniversityPortland, Oregon  97201
Florida Gynecologic OncologyFort Myers, Florida  33901
Jersey Shore Medical CenterNeptune, New Jersey  07754
Decatur Memorial HospitalDecatur, Illinois  62526
Tulane University Health Sciences CenterNew Orleans, Louisiana  70112
Louisiana State University Health Science CenterNew Orleans, Louisiana  70112
Virginia Commonwealth UniversityRichmond, Virginia  
Lankenau HospitalWynnewood, Pennsylvania  19096
Central Georgia Gynecologic OncologyMacon, Georgia  31201
Holy Cross HospitalSilver Spring, Maryland  20910
Montana Cancer SpecialistsMissoula, Montana  59807-7877
Providence Saint Joseph Medical CenterBurbank, California  91505-4866
Florida HospitalOrlando, Florida  32803
Memorial Health University Medical CenterSavannah, Georgia  31404
Hillcrest Hospital Cancer CenterMayfield Heights, Ohio  44124
Harrison Medical CenterBremerton, Washington  98310
Phoenixville HospitalPhoenixville, Pennsylvania  19460
University of Chicago Comprehensive Cancer CenterChicago, Illinois  60637-1470
M D Anderson Cancer CenterHouston, Texas  77030
Northern Indiana Cancer Research ConsortiumSouth Bend, Indiana  
Rohnert Park Cancer CenterRohnert Park, California  94928
South Sacramento Cancer CenterSacramento, California  95823
Northern Virginia Pelvic Surgery AssociatesAnnandale, Virginia  22003
Virginia Oncology Associates - Lake WrightNorfolk, Virginia  23502
University of CincinnatiCincinnati, Ohio  45267-0502
Hawaii Medical Center EastHonolulu, Hawaii  96817
Vince Lombardi Cancer Clinic - OshkoshOshkosh, Wisconsin  54904
Penn State Milton S Hershey Medical CenterHershey, Pennsylvania  17033
The Community HospitalMunster, Indiana  46321
New Ulm Medical CenterNew Ulm, Minnesota  56073
Froedtert and the Medical College of WisconsinMilwaukee, Wisconsin  53226
Wake Forest University Health SciencesWinston-Salem, North Carolina  27157
OSF Saint Francis Medical CenterPeoria, Illinois  61637
Northside HospitalAtlanta, Georgia  30342
Valley Medical Oncology Consultants-Castro ValleyCastro Valley, California  94546
Valley Medical Oncology Consultants-FremontFremont, California  94538
Kaiser Permanente, FremontFremont, California  94538
Kaiser Permanente, HaywardHayward, California  94545
Bay Area Breast Surgeons IncOakland, California  94609
Bay Area Tumor Institution CCOPOakland, California  94609
Tom K Lee IncOakland, California  94609
Kaiser Permanente-OaklandOakland, California  94611
Kaiser Permanente-Redwood CityRedwood City, California  94063
Kaiser Permanente-RichmondRichmond, California  94801
Kaiser Permanente-RosevilleRoseville, California  95661
Sutter General HospitalSacramento, California  95816
Kaiser Permanente-South SacramentoSacramento, California  95823
Kaiser Permanente - SacramentoSacramento, California  95825
Kaiser Permanente-San FranciscoSan Francisco, California  94115
University of California San Francisco Medical Center-Mount ZionSan Francisco, California  94115
Kaiser Permanente-Santa Teresa-San JoseSan Jose, California  95119
Doctors Medical Center- JC Robinson Regional Cancer CenterSan Pablo, California  94806
Kaiser Permanente-San RafaelSan Rafael, California  94903
Kaiser Permanente-Santa RosaSanta Rosa, California  95403
Kaiser Permanente-South San FranciscoSouth San Francisco, California  94080
Kaiser Permanente-StocktonStockton, California  95210
Kaiser Permanente-VallejoVallejo, California  94589
Kaiser Permanente-Walnut CreekWalnut Creek, California  94596
Danbury HospitalDanbury, Connecticut  06810
Saint Francis Hospital and Medical CenterHartford, Connecticut  06105
The Hospital of Central ConnecticutNew Britain, Connecticut  06050
Stamford HospitalStamford, Connecticut  06904
The Watson ClinicLakeland, Florida  33805
M D Anderson Cancer Center- OrlandoOrlando, Florida  32806
Oncare Hawaii Inc-POB IIHonolulu, Hawaii  96813
Oncare Hawaii Inc-KuakiniHonolulu, Hawaii  96817
University of HawaiiHonolulu, Hawaii  96813
Pacific Cancer Institute of MauiWailuku, Hawaii  96793
Rush - Copley Medical CenterAurora, Illinois  60504
John H Stroger Jr Hospital of Cook CountyChicago, Illinois  60612-3785
Resurrection HealthcareChicago, Illinois  60631
Provena Saint Mary's HospitalKankakee, Illinois  60901
Garneau, Stewart C MD (UIA Investigator)Moline, Illinois  61265
Porubcin, Michael MD (UIA Investigator)Moline, Illinois  61265
Community Cancer Center FoundationNormal, Illinois  61761
Illinois CancerCare-Ottawa ClinicOttawa, Illinois  61350
Ottawa Regional Hospital and Healthcare CenterOttawa, Illinois  61350
Pekin Cancer Treatment CenterPekin, Illinois  61554
Illinois Oncology Research Association CCOPPeoria, Illinois  61615
Illinois CancerCare-PeoriaPeoria, Illinois  61615
Illinois Valley HospitalPeru, Illinois  61354
Saint Francis Hospital and Health CentersBeech Grove, Indiana  46107
Fort Wayne Medical Oncology and Hematology Inc - State BoulevardFort Wayne, Indiana  46845
Saint Anthony Memorial Health CenterMichigan City, Indiana  46360
Reid Hospital and Health Care ServicesRichmond, Indiana  47374
McFarland ClinicAmes, Iowa  50010
Constantinou, Costas L MD (UIA Investigator)Bettendorf, Iowa  52722
Cedar Rapids Oncology AssociationCedar Rapids, Iowa  52403
Mercy HospitalCedar Rapids, Iowa  52403
Medical Oncology and Hematology Associates-West Des MoinesClive, Iowa  50325
Iowa Oncology Research Association CCOPDes Moines, Iowa  50309
Mercy Medical Center - Des MoinesDes Moines, Iowa  50314
Medical Oncology and Hematology Associates-Des MoinesDes Moines, Iowa  50309
Mercy Medical Center - North IowaMason City, Iowa  50401
Mercy Medical Center-Sioux CitySioux City, Iowa  51104
Saint Luke's Regional Medical CenterSioux City, Iowa  51104
Medical Center of LouisianaNew Orleans, Louisiana  70112
Highland ClinicShreveport, Louisiana  71105
Holy Family HospitalMethuen, Massachusetts  01844
Michigan Cancer Research Consortium Community Clinical Oncology ProgramAnn Arbor, Michigan  48106
Oakwood HospitalDearborn, Michigan  48123
Saint John Hospital and Medical CenterDetroit, Michigan  48236
Green Bay Oncology - EscanabaEscanaba, Michigan  49431
Grand Rapids Clinical Oncology ProgramGrand Rapids, Michigan  49503
Saint Mary's Health CareGrand Rapids, Michigan  49503
Spectrum Health at Butterworth CampusGrand Rapids, Michigan  49503
Green Bay Oncology - Iron MountainIron Mountain, Michigan  49801
Allegiance HealthJackson, Michigan  49201
Sparrow HospitalLansing, Michigan  48912
Saint Mary Mercy HospitalLivonia, Michigan  48154
Mercy Health Partners-Mercy CampusMuskegon, Michigan  49443
Saint Joseph Mercy OaklandPontiac, Michigan  48341-2985
Saint Joseph Mercy Port HuronPort Huron, Michigan  48060
Saint Mary's of MichiganSaginaw, Michigan  48601
Lakeland HospitalSt. Joseph, Michigan  49085
Saint John Macomb-Oakland HospitalWarren, Michigan  48093
Miller-Dwan HospitalDuluth, Minnesota  55805
Saint Luke's Hospital of DuluthDuluth, Minnesota  55805
Unity HospitalFridley, Minnesota  55432
Saint John's Hospital - HealtheastMaplewood, Minnesota  55109
Minnesota Oncology Hematology PA-MaplewoodMaplewood, Minnesota  55109
North Memorial Medical Health CenterRobbinsdale, Minnesota  55422
Park Nicollet Clinic - Saint Louis ParkSaint Louis Park, Minnesota  55416
Minnesota Oncology and Hematology PA-WoodburyWoodbury, Minnesota  55125
Freeman Health SystemJoplin, Missouri  64804
Saint Luke's Cancer InstituteKansas City, Missouri  64111
Saint Luke's Hospital of Kansas CityKansas City, Missouri  64111
Saint Joseph Health CenterKansas City, Missouri  64114
Liberty Radiation Oncology ClinicKansas City, Missouri  64116
Ozark Health Ventures LLC dba Cancer Research for The Ozarks SpringfieldSpringfield, Missouri  65802
Saint John's HospitalSpringfield, Missouri  65804
Cox Medical CenterSpringfield, Missouri  65807
Hematology-Oncology Centers of the Northern Rockies PCBillings, Montana  59101
Saint Vincent HealthcareBillings, Montana  59101
Billings ClinicBillings, Montana  59107-7000
Saint James Community Hospital and Cancer Treatment CenterButte, Montana  59701
Benefis Healthcare- Sletten Cancer InstituteGreat Falls, Montana  59405
Saint Peter's Community HospitalHelena, Montana  59601
Glacier Oncology PLLCKalispell, Montana  59901
Saint Patrick Hospital - Community HospitalMissoula, Montana  59802
Good Samaritan HospitalKearney, Nebraska  68847
Lincoln Medical Education Foundation Cancer Resource CenterLincoln, Nebraska  68510
Missouri Valley Cancer Consortium CCOPOmaha, Nebraska  68106
Cooper Hospital University Medical CenterCamden, New Jersey  08103
Fox Chase Cancer Center at Virtua Memorial Hospital of Burlington CountyMount Holly, New Jersey  08060
South Jersey HealthcareVineland, New Jersey  08360
Virtua West Jersey Hospital VoorheesVoorhees, New Jersey  08043
Memorial Medical Center - Las CrucesLas Cruces, New Mexico  88011
Orange Regional Medical CenterMiddletown, New York  10940
New York University Langone Medical CenterNew York, New York  10016
Columbia University Medical CenterNew York, New York  10032
State University of New York Upstate Medical UniversitySyracuse, New York  13210
Alamance Regional Medical CenterBurlington, North Carolina  27216
Wayne Memorial HospitalGoldsboro, North Carolina  27534
Margaret R Pardee Memorial HospitalHendersonville, North Carolina  28791
Saint Alexius Medical CenterBismarck, North Dakota  58501
Aultman Health FoundationCanton, Ohio  44710
Doctors HospitalColumbus, Ohio  43228
Grant Medical CenterColumbus, Ohio  43215
Mount Carmel Health Center WestColumbus, Ohio  43222
Good Samaritan Hospital - DaytonDayton, Ohio  45406
Dayton CCOPDayton, Ohio  45429
Samaritan North Health CenterDayton, Ohio  45415
Blanchard Valley HospitalFindlay, Ohio  45840
Atrium Medical Center-Middletown Regional HospitalFranklin, Ohio  45005-1066
Kettering Medical CenterKettering, Ohio  45429
Saint Rita's Medical CenterLima, Ohio  45801
Marietta Memorial HospitalMarietta, Ohio  45750
Upper Valley Medical CenterTroy, Ohio  45373
Saint Ann's HospitalWesterville, Ohio  43081
Genesis HealthCare SystemZanesville, Ohio  43701
Legacy Good Samaritan Hospital and Medical CenterPortland, Oregon  97210
Northwest Cancer Specialists-Rose Quarter Cancer CenterPortland, Oregon  97227
Saint Luke's HospitalBethlehem, Pennsylvania  18015
Hematology and Oncology Associates of North East PennsylvaniaScranton, Pennsylvania  18508
Scranton Hematology OncologyScranton, Pennsylvania  18510
Mercy HospitalScranton, Pennsylvania  18501
Associates In Hematology Oncology PC-UplandUpland, Pennsylvania  19013
Mainline Health CCOPWynnewood, Pennsylvania  19096
AnMed Health HospitalAnderson, South Carolina  29621
Greenville CCOPGreenville, South Carolina  29615
Upstate Carolina CCOPSpartanburg, South Carolina  29303
Sanford Cancer Center-Oncology ClinicSioux Falls, South Dakota  57104
Southwest VA Regional Cancer CenterNorton, Virginia  24273
Harrison Bremerton Hematology and OncologyBremerton, Washington  98310
Swedish Medical Center-First HillSeattle, Washington  98122-4307
Saint Joseph Medical CenterTacoma, Washington  98405
Langlade Hospital and Cancer CenterAntigo, Wisconsin  54409
Saint Vincent HospitalGreen Bay, Wisconsin  54301
Green Bay Oncology Limited at Saint Mary's HospitalGreen Bay, Wisconsin  54303
Saint Mary's HospitalGreen Bay, Wisconsin  54303
Green Bay Oncology at Saint Vincent HospitalGreen Bay, Wisconsin  54301-3526
Aurora BayCare Medical CenterGreen Bay, Wisconsin  54311-6519
Bay Area Medical CenterMarinette, Wisconsin  54143
Marshfield Clinic-Minocqua CenterMinocqua, Wisconsin  54548
Oconomowoc Memorial Hospital-ProHealth Care IncOconomowoc, Wisconsin  53066-3896
Green Bay Oncology - Oconto FallsOconto Falls, Wisconsin  54154
Marshfield Clinic at James Beck Cancer CenterRhinelander, Wisconsin  54501
Marshfield Clinic-Rice Lake CenterRice Lake, Wisconsin  54868
Green Bay Oncology - Sturgeon BaySturgeon Bay, Wisconsin  54235
Aspirus Regional Cancer CenterWausau, Wisconsin  54401
Cancer Care Associates-YaleTulsa, Oklahoma  74136-1929
Women and Infants HospitalProvidence, Rhode Island  02905
University of Maryland Greenebaum Cancer CenterBaltimore, Maryland  21201
Lake University Ireland Cancer CenterMentor, Ohio  44060
Lyndon Baines Johnson General HospitalHouston, Texas  77030
Women's Cancer AssociatesSaint Petersburg, Florida  33701
Stony Brook University Medical CenterStony Brook, New York  11794
Roger Maris Cancer CenterFargo, North Dakota  58122
Lahey Clinic Medical CenterBurlington, Massachusetts  01805
Elkhart ClinicElkhart, Indiana  46515
John Muir Medical Center-Concord CampusConcord, California  94520
University of Colorado Cancer Center - Anschutz Cancer PavilionAurora, Colorado  80045
Kootenai Cancer CenterPost Falls, Idaho  83854
Illinois CancerCare-BloomingtonBloomington%, Illinois  61701
Illinois CancerCare-CantonCanton, Illinois  61520
Illinois CancerCare-CarthageCarthage, Illinois  62321
Illinois CancerCare-EurekaEureka, Illinois  61530
Illinois CancerCare-HavanaHavana, Illinois  62644
Illinois CancerCare-Kewanee ClinicKewanee, Illinois  61443
Illinois CancerCare-MacombMacomb, Illinois  61455
Illinois CancerCare-MonmouthMonmouth, Illinois  61462
Illinois CancerCare-Community Cancer CenterNormal, Illinois  61761
Illinois CancerCare-PekinPekin, Illinois  61603
Illinois CancerCare-PeruPeru, Illinois  61354
Illinois CancerCare-PrincetonPrinceton, Illinois  61356
Illinois CancerCare-Spring ValleySpring Valley, Illinois  61362
Michiana Hematology Oncology PC-ElkhartElkhart, Indiana  46514
Michiana Hematology Oncology PC-PlymouthPlymouth, Indiana  46563
Michiana Hematology Oncology PC-South BendSouth Bend, Indiana  46601
Michiana Hematology Oncology-PC WestvilleWestville, Indiana  46391
The Memorial Hospital at EastonEaston, Maryland  21601
Michiana Hematology Oncology PC-NilesNiles, Michigan  49120
Renown Regional Medical CenterReno, Nevada  89502
Cancer Centers of the Carolinas - FarisGreenville, South Carolina  29605
University of Tennessee - KnoxvilleKnoxville, Tennessee  37920
Sandra L Maxwell Cancer CenterCedar City, Utah  84720
Intermountain Medical CenterMurray, Utah  84157
Utah Valley Regional Medical CenterProvo, Utah  84603
Dixie Medical Center Regional Cancer CenterSaint George, Utah  84770
Utah Cancer Specialists-Salt Lake CitySalt Lake City, Utah  84106
Virginia Oncology Associates-HamptonHampton, Virginia  23666
Marshfield Clinic-Chippewa CenterChippewa Falls, Wisconsin  54729
Holy Family Memorial HospitalManitowoc, Wisconsin  54221
Vince Lombardi Cancer Clinic-SheboyganSheboygan, Wisconsin  53081
Marshfield Clinic Cancer Care at Saint Michael's HospitalStevens Point, Wisconsin  54481
Aurora Medical Center in SummitSummit, Wisconsin  53066
Vince Lombardi Cancer ClinicTwo Rivers, Wisconsin  54241
Olive View-University of California Los Angeles Medical CenterSylmar, California  91342
Hawaii Minority Based CCOPHonolulu, Hawaii  96813
Advocate Lutheran General HospitalPark Ridge, Illinois  60068
Saint Elizabeth Medical Center SouthEdgewood, Kentucky  41017
Maine Medical Center-Bramhall CampusPortland, Maine  04102
Gynecologic Oncology of West Michigan PLLCGrand Rapids, Michigan  49546
Center of Hope at Renown Medical CenterReno, Nevada  89502
Montefiore Medical Center-Weiler DivisionBronx, New York  10461
State University of New York Downstate Medical CenterBrooklyn, New York  11203
Monter Cancer CenterLake Success, New York  11042
Hope, A Women's Cancer CenterAsheville, North Carolina  28816
Magee-Womens Hospital - University of Pittsburgh Medical CenterPittsburgh, Pennsylvania  15213
Black Hills Obstetrics and GynecologyRapid City, South Dakota  57701
Carilion Clinic Gynecological OncologyRoanoke, Virginia  24016
Aurora Women's Pavilion of Aurora West Allis Medical CenterWest Allis, Wisconsin  53227
Long Beach Memorial Medical Center-Todd Cancer InstituteLong Beach, California  90806
Kaiser Permanente Medical Care Program - Los Angeles Medical Center & Sunset HospitalLos Angeles, California  90027
Rocky Mountain Gynecologic Oncology PCEnglewood, Colorado  80110
Norton Health Care Pavilion - DowntownLouisville, Kentucky  40202
Saint Dominic-Jackson Memorial HospitalJackson, Mississippi  39216
Southwest Gynecologic Oncology Associates IncAlbuquerque, New Mexico  87106
FirstHealth of the Carolinas-Moore Regional HosiptalPinehurst, North Carolina  28374
Women's Cancer Center of NevadaLas Vegas, Nevada  89109
Arizona Cancer Center at University Medical Center NorthTucson, Arizona  85719
Arizona Cancer Center at UMC Orange GroveTucson, Arizona  85704
Kaiser Permanente-Deer Valley Medical CenterAntioch, California  94531
Kaiser Permanente Oakland-BroadwayOakland, California  94611
Kaiser Permanente-Rancho Cordova Cancer CenterRancho Cardova, California  95670
The Permanente Medical Group-Roseville Radiation OncologyRoseville, California  95678
Kaiser Permanente Radiation Oncology Cancer Treatment CenterSanta Clara, California  95051
Kaiser Permanente Cancer Treatment CenterSouth San Francisco, California  94080
Kaiser Permanente Medical Center-VacavilleVacaville, California  95688
Kaiser Permanente-Rock CreekLafayette, Colorado  80026
Saint Vincent's Medical CenterBridgeport, Connecticut  06606
Kaiser Permanente Moanalua Medical CenterHonolulu, Hawaii  96819
Wilcox Memorial Hospital and Kauai Medical ClinicLihue, Hawaii  96766-1099
Spector, David MD (UIA Investigator)Moline, Illinois  61265
Central DuPage Hospital Cancer CenterWarrenville, Illinois  60555
Saint Luke's South HospitalOverland Park, Kansas  66213
Kansas City CCOPPrairie Village, Kansas  66208
Heartland Hematology and Oncology Associates IncorporatedKansas City, Missouri  64118
Saint Joseph Oncology IncSaint Joseph, Missouri  64507
The Mark H Zangmeister CenterColumbus, Ohio  43219
Southern Ohio Medical CenterPortsmouth, Ohio  45662
Saint Charles Medical Center-BendBend, Oregon  97701
Saint Francis HospitalGreenville, South Carolina  29601
Hematology Oncology Associates of Fredericksburg IncFredericksburg, Virginia  22401
Providence Regional Cancer PartnershipEverett, Washington  98201
Gundersen LutheranLa Crosse, Wisconsin  54601
Alegent Health Lakeside HospitalOmaha, Nebraska  68130
Stanford University Hospitals and ClinicsStanford, California  94305
Kaiser Permanente-FranklinDenver, Colorado  80205
Siouxland Hematology Oncology AssociatesSioux City, Iowa  51101
Palo Alto Medical Foundation-Gynecologic OncologyMountain View, California  94040
Sudarshan K Sharma MD Limted-Gynecologic OncologyHinsdale, Illinois  60521
Saint Vincent Oncology CenterIndianapolis, Indiana  46260
University of Massachusetts Memorial Health CareWorcester, Massachusetts  01605
The Women's Institute for Gynecologic Cancer and Special Pelvic SurgeryPhillipsburg, New Jersey  08865
PeaceHealth Medical Group PCBellingham, Washington  98226
Skagit Valley Hospital Regional Cancer Care CenterMount Vernon, Washington  98274
Olympic Medical Cancer Care CenterSequim, Washington  98384
Rockwood Cancer Treatment CenterSpokane, Washington  99204
Providence Saint Mary Regional Cancer CenterWalla Walla, Washington  99362
Aurora Saint Luke's Medical CenterMilwaukee, Wisconsin  53215
Methodist West HospitalWest Des Moines, Iowa  50266-7700
Jonsson Comprehensive Cancer CenterLos Angeles, California  90095
Carle Foundation - Carle Cancer CenterUrbana, Illinois  61801
Michiana Hematology Oncology PC-MishawakaMishawaka, Indiana  46545-1470
Oncology Associates at Mercy Medical CenterCedar Rapids, Iowa  52403
Marie Yeager Cancer CenterSaint Joseph, Michigan  49085
Sanford Clinic North-FargoFargo, North Dakota  58102
Sanford Medical Center-FargoFargo, North Dakota  58122
Summa Akron City HospitalAkron, Ohio  44304
Park Nicollet Frauenshuh Cancer CenterMinneapolis, Minnesota  55416
Gynecologic Oncology GroupPhiladelphia, Pennsylvania  19103
Sanford USD Medical Center - Sioux FallsSioux Falls, South Dakota  57117-5134
Genesys Regional Medical Center-West Flint CampusFlint, Michigan  48532
Sanford Clinic North-BemidgiBemidji, Minnesota  56601
Essentia Health Saint Joseph's Medical CenterBrainerd, Minnesota  56401
Essentia Health Duluth Clinic CCOPDuluth, Minnesota  55805
Essentia Health Saint Mary's Medical CenterDuluth, Minnesota  55805
Sanford Bismarck Medical CenterBismarck, North Dakota  58501
Community Howard Regional HealthKokomo, Indiana  46904
Indiana University Health La Porte HospitalLa Porte, Indiana  46350
Saint Joseph Regional Medical Center-MishawakaMishawaka, Indiana  46545-1470
Christiana Care Health System-Christiana HospitalNewark, Delaware  19718
Bronson Battle CreekBattle Creek, Michigan  49017
Springfield Regional Medical CenterSpringfield, Ohio  45505
Cleveland Clinic Cancer Center/Fairview HospitalCleveland, Ohio  44111
Saint Joseph's Hospital and Medical CenterPhoenix, Arizona  85013
Southeast Gynecologic Oncology AssociatesJacksonville, Florida  32204
The James Graham Brown Cancer Center at University of LouisvilleLouisville, Kentucky  40202
Women's Cancer Care Associates LLCAlbany, New York  12208
Island Gynecologic OncologyBrightwaters, New York  11718
Fletcher Allen Health Care-Medical CenterBurlington, Vermont  05401
Marin Cancer Care IncGreenbrae, California  94904
Lake Region Healthcare Corporation-Cancer CareFergus Falls, Minnesota  56537
Harrison Poulsbo Hematology and OncologyPoulsbo, Washington  98370
Mercy Cancer Center-West LakesClive, Iowa  50325
Mercy Medical Center-West LakesWest Des Moines, Iowa  50266
D N Greenwald CenterMukwonago, Wisconsin  53149
Pikeville Medical CenterPikeville, Kentucky  41501