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A Phase 1/2, Single Arm Study To Assess the Efficacy and Safety of Rigosertib (ON 01910.Na) Administered as 72-Hour and 120-Hour Continuous Intravenous Infusions Every Other Week for Two Cycles Then as Twice Daily Oral Capsules Given Continuously in Patients With Relapsed/Refractory Acute Myeloid or Lymphocytic Leukemia or Transformed Myeloproliferative Neoplasms


Phase 1/Phase 2
18 Years
N/A
Open (Enrolling)
Both
Acute Myelocytic Leukemia, Acute Lymphocytic Leukemia, Myeloproliferative Disease, Chronic Myeloid Leukemia

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Trial Information

A Phase 1/2, Single Arm Study To Assess the Efficacy and Safety of Rigosertib (ON 01910.Na) Administered as 72-Hour and 120-Hour Continuous Intravenous Infusions Every Other Week for Two Cycles Then as Twice Daily Oral Capsules Given Continuously in Patients With Relapsed/Refractory Acute Myeloid or Lymphocytic Leukemia or Transformed Myeloproliferative Neoplasms


This is a single center, open-label, phase 1/2 study in which 2 to 34 patients with
refractory acute myeloid or lymphocytic leukemia or transformed myeloproliferative neoplasms
(MPNs)who meet all other inclusion/exclusion criteria will be administered a daily dose of
2400 mg ON 01910.Na dose as a intravenous continuous infusion (IVCI) over 24 hours for 72 to
120 consecutive hours every 2 weeks for the first 4 weeks then will receive oral rigosertib
at a 560 mg twice-daily dose as capsules taken continuously.

In the phase 1 component of the trial, a standard dose escalation scheme will be followed
with the enrolment of at least three patients treated with a daily dose of 2400 mg ON
01910.Na IVCI over 24 hours for 72 hours. The dose escalation scheme will follow a
traditional dose escalation rule, also known as the "3+3" rule:

If none of the initial three patients treated in the 72-hour cohort experience dose-limiting
toxicity (DLT), during the first two 2-week cycles, then a new cohort of three patients will
be treated at the same 2400 mg/24h daily dose but for an increased 120 hours duration.

DLT is defined as an adverse event possibly related to ON 01910.Na that is:

- Grade ≥ 3 non-hematological toxicity other than nausea, vomiting, diarrhea, fever,
esophagitis/dysphagia

- Grade ≥ 3 nausea and vomiting uncontrolled by antiemetics; grade ≥ 3 diarrhea
uncontrolled by antidiarrheal agents; grade ≥ 3 drug-induced fever uncontrolled by
antipyretics; grade ≥3 metabolic abnormalities that are not controlled by optimal
supportive care measures

- Grade ≥ 3 stomatitis and/or esophagitis/dysphagia lasting > 3 days

- Marrow cellularity <5% on day 42 or later (6 weeks) from start of therapy without
evidence of leukemia

If one of the three patients in the 72-hour cohort experiences a DLT during the first two
cycles, then three additional patients will be treated for the same 72 hours duration.
Escalation to the 120-hour cohort will proceed only if no more than one of the six patients
treated in the 72-hour cohort experiences a DLT.

If two or more patients in the 72-hour cohort experience DLT during the first two cycles,
then the maximum tolerated dose (MTD) will have been exceeded, no further dosing extension
will occur, and a full safety review will determine if further enrollment of patients will
proceed.

If none of the initial three patients in the 120-hour cohort experiences DLT during the
first two cycles, this regimen will be confirmed as the Maximum Tolerated Dose (MTD) and no
further dose escalation will occur.

If one of the three patients in the 120-hour cohort experiences DLT during the first two
cycles, then three additional patients will be treated for the same duration. If no more
than one patient experiences a DLT, the 120-hour regimen will be confirmed as the Maximum
Tolerated Dose (MTD) and no further dose escalation will occur.

If two or more patients in the 120 hours cohort experience DLT during the first two cycles,
then the maximum tolerated dose (MTD) will be determined to be 2400 mg/24h administered for
72 hours every other week.

Once the phase 1 portion of the study is completed, accrual to the phase 2 portion will
begin. Patients treated at the MTD during the phase 1 portion will be included in the phase
2 component and will be evaluated for response and secondary end points.

The total study duration is 30 weeks, which includes a 2-week screening phase, a 24-week
dosing phase (4-week rigosertib CIV administration, followed by 20 weeks of oral rigosertib
administration), and a 4-week follow-up phase that begins after the last dose of rigosertib.
Beginning at week 5, patients will be assessed for response every time a complete blood
count (CBC) is performed and followed up.

Patients who achieve by week 24 a response or stabilization of their disease are eligible to
receive an additional 24 weeks of rigosertib at the same dose and will be followed up.


Inclusion Criteria:



1. Histologically documented or cytologically confirmed diagnosis of one of the
following hematological malignancies:

- Acute myelocytic leukemia (AML) refractory to standard induction treatment, or
relapsed after standard therapy (including transformed myeloproliferative
diseases with at least 10% blasts in bone marrow and chronic myeloid leukemia in
a blast phase)

- Transformed myeloproliferative neoplasms (MPNs; i.e., myelofibrosis, essential
thrombocythemia (ET), polycythemia vera (PV)) with at least 10% blasts in bone
marrow and chronic myeloid leukemia in a blast phase refractory or relapsing
after standard therapy

- Acute lymphocytic leukemia (ALL) refractory to induction treatment, or relapsed
after standard therapy

2. Patients should not have received any prior chemotherapy for their leukemia or
transformed MPN within 14 days and should have recovered from any toxicity related to
prior chemotherapy to at least grade 1. In the presence of rapidly proliferating
disease, patients can be included after a washout period of 7 days. Hydroxyurea can
be administered as clinically indicated, and no washout is required.

3. Patients may not be candidates for, or must have declined, bone marrow
transplantation from an HLA-identical donor in the immediate future (ie, within 4
weeks) or other chemotherapeutic regimens known to produce consistent remissions.

4. Patients with known meningeal infiltration may be enrolled only if radiation has been
completed, and a clearing of peripheral blood blasts has been noted. Intrathecal
therapy can be continued if judged to be in the best interest of the patient to
prevent recurrence, provided there is no toxicity associated with it and there has
been clearance of blasts in the cerebrospinal fluid.

5. ECOG Performance Status 0, 1 or 2.

6. Willing to adhere to the prohibitions and restrictions specified in this protocol.

7. Patient must have signed an informed consent document indicating that he/she
understands the purpose of and procedures required for the study and is willing to
participate in the study.

Exclusion Criteria:

1. Any active malignancy within the past year except basal cell or squamous cell skin
cancer or carcinoma in situ of the cervix or breast.

2. Known HIV-1 seropositivity.

3. Uncontrolled intercurrent illness including, but not limited to symptomatic
congestive heart failure, unstable angina pectoris or cardiac arrhythmia.

4. Uncontrolled active systemic infection not adequately responding to appropriate
therapy.

5. Total bilirubin ≥ 1.5 mg/dL not related to hemolysis or Gilbert's disease.

6. ALT or AST ≥ 2.5 X ULN.

7. Serum creatinine ≥ 2.0 mg/dL.

8. Ascites requiring active medical management including paracentesis, or hyponatremia
(defined as serum sodium value of <130 Meq/L).

9. Female patients who are pregnant or lactating; Male patients with female sexual
partners who are unwilling to follow the strict contraception requirements (condom
use). Patients of reproductive potential who do not agree to use adequate
contraceptive before entry and throughout the study; Female patients with
reproductive potential who do not have a negative serum or urine beta-HCG pregnancy
test at screening.

10. Major surgery without full recovery or major surgery within 3 weeks of rigosertib
treatment start.

11. Uncontrolled hypertension (defined as a systolic pressure equal to or greater than
160 and/or a diastolic pressure equal to or greater than 100).

12. New onset seizures (within 3 months prior to the first dose of rigosertib) or poorly
controlled seizures

13. Any concurrent investigational agent or chemotherapy, radiotherapy or immunotherapy.

14. Psychiatric illness/social situations that would limit the patient's ability to
tolerate and/or comply with study requirements.

Type of Study:

Interventional

Study Design:

Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Outcome Measure:

Dose Limiting Toxicity (DLT)

Outcome Description:

DLT: adverse event possibly related that is: Grade ≥ 3 non-hematological toxicity other than nausea, vomiting, diarrhea, fever, esophagitis/dysphagia Grade ≥ 3 nausea and vomiting uncontrolled by antiemetics; grade ≥ 3 diarrhea uncontrolled by antidiarrheal agents; grade ≥ 3 drug-induced fever uncontrolled by antipyretics; grade ≥3 metabolic abnormalities that are not controlled by optimal supportive care measures Grade ≥ 3 stomatitis and/or esophagitis/dysphagia lasting > 3 days Marrow cellularity <5% on day 42 or later (6 weeks) from start of therapy without evidence of leukemia

Outcome Time Frame:

Up to 8 months

Safety Issue:

Yes

Principal Investigator

Jorge Cortes, MD

Investigator Role:

Principal Investigator

Investigator Affiliation:

M.D. Anderson Cancer Center

Authority:

United States: Food and Drug Administration

Study ID:

04-19

NCT ID:

NCT01167166

Start Date:

July 2010

Completion Date:

January 2014

Related Keywords:

  • Acute Myelocytic Leukemia
  • Acute Lymphocytic Leukemia
  • Myeloproliferative Disease
  • Chronic Myeloid Leukemia
  • Acute Myelocytic Leukemia
  • Acute Lymphocytic Leukemia
  • Myeloproliferative Disease
  • Myelofibrosis
  • Essential thrombocythemia
  • Polycythemia vera
  • Chronic Myeloid Leukemia
  • Leukemia
  • Leukemia, Lymphoid
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma
  • Leukemia, Myeloid, Acute
  • Leukemia, Myeloid
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive
  • Myeloproliferative Disorders

Name

Location

University of Texas M. D. Anderson Cancer CenterHouston, Texas  77030