Inclusion Criteria:

- Diagnosis of an unresectable, non-pancreatic malignancy, including gastric, small
intestinal, or proximal colonic malignancies, as well as malignancies of the liver
and bile ducts (based on above celiac plexus innervations)

- Pain directly related to the primary malignant process, as determined by the
referring oncologist

- Pain determined to be refractory to standard medical therapy, or when the medical
therapy is ineffective due to certain limitations (such as severe constipation), as
determined by the referring oncologist

- Willingness to undergo EUS-guided CPN

- Age > 18 years

- ECOG performance status of grades 0-3 [7]

- The patient will need to sign informed consent prior to inclusion in this study

Exclusion Criteria:

- Unable or unwilling to undergo an EUS-guided CPN

- Contraindication to anesthesia, as determine during the preoperative clearance
process

- Refractory coagulopathy (INR > 1.5) or thrombocytopenia (platelet count < 50,000), or
aspirin and/or clopidogrel use within 7 days of procedure

- Current pregnancy

- Prior celiac plexus block/neurolysis

- Allergy to local anesthetics

- ECOG performance status of grade 4 or higher