Inclusion Criteria:

- Those who are receiving Humira in accordance with its indications for treatment and
dosage regimens

- Those who are using Humira continuously

- Those with no current and no past history of malignant tumor

- Those evaluable for Disease Activity Score28-4erythrocyte sedimentation rate

- Patients who have been evaluated by Health Assessment Questionnaire or Modified
Health Assessment Questionnaire prior to initiation of Humira treatment (prior to
initial administration of Humira in the all-case survey)

Exclusion Criteria:

- Contraindications according to the Package Insert

- Patients who have serious infections

- Patients who have tuberculosis

- Patients with a history of hypersensitivity to any ingredient of Humira

- Patients who have demyelinating disease or with a history of demyelinating disease

- Patients who have cardiac failure congestive