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Comparison of Bone Morphogenetic Protein-4 and -7 Levels (BMP-4 and 7) in the Serum, Ovarian Follicle Aspirates and Ovarian Organ Culture Supernatants Between Healthy Controls and Patients With Polycystic Ovarian Syndrome (PCOS).


N/A
20 Years
35 Years
Open (Enrolling by invite only)
Female
Polycystic Ovarian Syndrome

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Trial Information

Comparison of Bone Morphogenetic Protein-4 and -7 Levels (BMP-4 and 7) in the Serum, Ovarian Follicle Aspirates and Ovarian Organ Culture Supernatants Between Healthy Controls and Patients With Polycystic Ovarian Syndrome (PCOS).


Female patients at ages 20-35 diagnosed with polycystic ovarian syndrome and age-matched
healthy control subjects will be enrolled in this study.

Blood samples will be obtained at early follicular phase during doctor's visit from PCOS
patients and control subjects.If the patient is amenorrheic at the time of visit, both
random blood samples and another sample at early follicular phase after induction of
withdrawal bleeding with progesterone.

Follicular fluids will be retrieved during oocyte pick-up procedure in patients undergoing
assisted reproduction for PCOS and control IVF patients whose infertility is not PCO
related.

Samples from ovaries will be collected at operation from PCOS patients and control subjects
if they already undergo any gynecologic laparotomi operations.

Collected samples will be cultured for 7 days and BMP-4 and -7 levels will be measured in
the culture fluid of the samples using ELISA method.


Inclusion Criteria:



- Healthy subjects and PCOS patients at ages 20-35 will be recruited for the study.

Exclusion Criteria:

- Those with any metabolic or endocrine problems other than PCOS will be excluded from
the study.

Type of Study:

Observational

Study Design:

Observational Model: Case Control, Time Perspective: Cross-Sectional

Principal Investigator

Bulent Urman, MD

Investigator Role:

Study Director

Investigator Affiliation:

VKV American Hospital Women's Health center

Authority:

Turkey: Ministry of Health

Study ID:

MAR.YC.2008.0276

NCT ID:

NCT01162447

Start Date:

February 2010

Completion Date:

February 2011

Related Keywords:

  • Polycystic Ovarian Syndrome
  • BMP- 4 and 7, polycystic ovarian syndrome
  • Polycystic Ovary Syndrome

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