Dose Escalating Study of Single Fraction Stereotactic Body Radiation Therapy (SBRT) for Patients With Hepatic Metastases
If the patient has met all the eligibility criteria, they will be registered to the study
After successful registration to the study and treatment planning session, patients will
receive a single fraction of radiation. The total dose a particular patient receives will
depend on the dose cohort they are enrolled into. Each treatment will last about one hour
and will be given in a particular position to help guide the beams of radiation toward the
cancer area. Although it is not mandatory, it is recommended that patients receive
corticosteroid premedication (e.g. Decadron 4-10 m.g. p.o. in a single dose or equivalent)
15-60 minutes prior to each treatment for the intended purpose of modulating immediate acute
inflammatory effects and providing anti-emetic support.
Allocation: Non-Randomized, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
The maximum tolerated dose of single fraction stereotactic radiotherapy in patients with hepatic metastases.
The dose of single fraction stereotactic radiotherapy will be escalated without exceeding the maximum tolerated dose in patients with hepatic metastases.
Jeffrey Meyer, MD
The University of Texas Southwestern Medical Center at Dallas
United States: Institutional Review Board
|The University of Texas Southwestern Medical Center||Dallas, Texas 75390|