Pilot Study of A One-Step Procedure for the Use of Autologous Bone Marrow Mesenchymal Stem Cells Stimulated by Proteins Scaffold to Heal Under Arthroscopy Full-Thickness Defects Articular Cartilage and Osteoarthrosis of the Knee.
Before the implantation of the mesenchymal stem cells, a knee arthroscopy procedure is made
for the debridement of the meniscal and cartilage lesions, with microperforation and
abrasion, preparation of the osteochondral defect to receive the transplantation, patellar
lateral release if necessary.
Then, the investigators use a fresh non-culture expanded autologous bone marrow derived
mesenchymal mononuclear stem cells, stimulated with a protein matrix and mixed in a collagen
hydroxyapatite scaffold. This cellular paste is transplanted in the prepared defect, under
arthroscopy, with injection of platelet rich plasma.
Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
IKS, International Knee Score
measure assess of the knee function
Michel Assor, MD
Knee and Lower Limb Institute, Marseille, France
France: Afssaps - Agence française de sécurité sanitaire des produits de santé (Saint-Denis)