Palliative Radiotherapy Followed by Chemotherapy Against Palliative Surgery in Patients With Rectal Cancer With Unresectable Synchronous Distant Metastases
Patients with symptomatic rectal cancer and unresectable metastases receive 25 Gy in 5
fractions of 5 Gy over 5 days to the pelvis and XELOX consolidating chemotherapy after one
week. Investigators arbitrarily assumed that palliative radiotherapy to the pelvis can
replace the immediate surgery if at least 30% of patients would avoid delayed surgery until
the end of their lives, or for at least 18 months in the case of long-term survival.
Allocation: Non-Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
percentage of patients not requiring palliative surgery during the follow-up
every three months
Krzysztof Bujko, Prof.
M. Sklodowska-Curie Memorial Cancer Centre Warsaw, Poland
Poland: Ministry of Science and Higher Education