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Detection of Infra-clinic Cortisol Adenoma (ACIC) in a Population of Android Obese With High Metabolic Risk: Contribution of Salivary Cortisol at 23 Hours


N/A
18 Years
N/A
Open (Enrolling)
Both
Obesity

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Trial Information

Detection of Infra-clinic Cortisol Adenoma (ACIC) in a Population of Android Obese With High Metabolic Risk: Contribution of Salivary Cortisol at 23 Hours


Inclusion Criteria:



- Adult patients (≥18 years)

- Signed informed consent

- Subjects affiliated with an appropriate social security system

- Body mass index above 30 kg/m2 and

- Pathological waist circumference according to criteria of NCEP ATPIII (men : 94 cm
and women : 80 cm)

Exclusion Criteria:

- Pregnancy

- Sepsis

- Recent surgery (less than 30 days)

- Any recent severe acute conditions requiring hospitalisation (less than 30 days)

- Recent use (< 7 days) of oral steroids, inhaled, dermal, collyrium, infiltration

- Long-term oral corticosteroids

- Nicotinic substitute or per os licorice in 2 weeks before the inclusion

Type of Study:

Interventional

Study Design:

Allocation: Non-Randomized, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Diagnostic

Outcome Measure:

Number of patients with positive salivary cortisol dosage among patients with positive serum cortisol dosage

Outcome Description:

The main objective of the study is to assess the sensitivity of the salivary cortisol dosage at 23 hours compared to the serum cortisol dosage at 8 am after overnight 1-mg dexamethasone suppression test as the reference method for the detection of ACIC in obese subjects

Safety Issue:

No

Principal Investigator

Bertrand CARIOU, Pr

Investigator Role:

Principal Investigator

Investigator Affiliation:

Nantes University Hospital

Authority:

France: Afssaps - Agence française de sécurité sanitaire des produits de santé (Saint-Denis)

Study ID:

09/12-I

NCT ID:

NCT01156519

Start Date:

June 2010

Completion Date:

August 2012

Related Keywords:

  • Obesity
  • Infra-clinic cortisol adenoma
  • Salivary cortisol
  • Obesity
  • Adenoma
  • Obesity

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