Inclusion Criteria:

5.1.1 Steroid dependent/refractory cGVHD defined as:

1. Dependent disease - Persistent cGVHD manifestations requiring a glucocorticoid dose
>= prednisone 0.25 mg/kg/day (0.5 mg/kg po qod) for at least 12 weeks.

2. Refractory disease - Progressive cGVHD manifestations despite treatment with a
glucocorticoid dose >= prednisone 0.5 mg/kg/day (1 mg/kg po qod) for at least 4
weeks.

5.1.2 Any previous treatments for cGVHD (except nilotinib). Participants may have
received nilotinib for other reasons besides cGVHD such as leukemia or solid tumor.

5.1.3 Participants must be receiving baseline systemic glucocorticoid therapy for cGVHD at
study entry. The dose of steroids must be stable for 14 days prior to starting nilotinib.

5.1.4 At the time of trial enrollment, participants may be receiving one or two other
immunosuppressive therapies in addition to glucocorticoids. Immunosuppressant doses must
be stable for 14 days prior to starting nilotinib. Monoclonal T or B cell antibodies must
be discontinued at least 28 days before starting nilotinib.

5.1.5 Chronic GVHD manifestations that can be followed on physical or laboratory exam. A
list of potential manifestations is presented in Appendix D.

1. Skin changes

2. Oral mucosa changes

3. Hepatic dysfunction

5.1.6 >= 18 years old

5.1.7 Life expectancy >= 6 months.

5.1.8 Karnofsky performance status >= 60 (defined as being unable to work, able to live at
home, and able to care for most personal needs but requiring occasional assistance from
others).

5.1.9 Laboratory parameters:

1. Creatinine < 1.5 x ULN

2. ANC > 1.5 x 10^9/L

3. Platelets > 100 x 10^9/L

4. Total bilirubin < 1.5 x ULN

5. AST (SGOT) and ALT (SGPT) < 2.5 x ULN

6. Serum amylase and lipase <= 1.5 x ULN

7. Alkaline phosphatase <= 2.5 x ULN

8. Patients must have the following laboratory values within normal limits at the local
institution lab or corrected to within normal limits with supplements prior to the
first dose of study medication:

Potassium Magnesium Phosphorus Calcium

5.1.10 Oxygen saturation during exertion maintained at >= 88% on room air.

5.1.11 Ability to understand and willingness to sign a written informed consent form.

5.1.12 Females with reproductive potential must have a negative pregnancy test <= 7 days
before starting nilotinib. Reproductive potential will be defined as having at least 1
menstrual period in the past 12 months. Male and female subjects with reproductive
potential agree to the use of barrier contraception during their treatment and for up to 3
months after the last dose.

5.1.13 Careful rationalization of concomitant medications with the intent to discontinue
or change to alternative medications when any concomitant medications are identified that
have the potential to prolong the QTcB interval or are associated with an increased risk
of torsades de pointes. (Appendix B)

5.1.14 . Careful rationalization of concomitant medications with the intent to discontinue
or change to alternative medications if any concomitant medications are identified to be
strong CYP3A4 inhibitors. (Appendix C)

5.1.15 Myeloablative or non-myeloablative allogeneic hematopoietic cell transplant.

Exclusion Criteria:5.2.1 Currently receiving or has received within 28 days of starting
study drug nilotinib or any other tyrosine kinase inhibitor.

5.2.2 Received any anti-T or anti-B cell monoclonal antibody <= 28 days prior to the
anticipated start of study drug.

5.2.3 Currently receiving > two immunosuppressants other than glucocorticoids.

5.2.4 Currently receiving a calcineurin inhibitor and sirolimus

5.2.5 Received any investigational agents <= 28 days before starting nilotinib.

5.2.6 Impaired cardiac function including any one of the following:

1. Clinically significant resting brachycardia (<50 beats per minute).

2. QTc > 450 msec on baseline ECG. If QTc >450 msec and electrolytes are not within
normal ranges, electrolytes should be corrected and then the patient re-screened for
QTc.

3. Myocardial infarction within 12 months prior to starting study.

4. Other clinically significant uncontrolled heart disease (e.g. unstable angina,
congestive heart failure or uncontrolled hypertension).

5. History of or presence of clinically significant ventricular or atrial
tachyarrhythmias. (including congenital long QT syndrome or a known family history of
congenital long QT syndrome)

5.2.7 Allogeneic cell infusion within 100 days

5.2.8 Uncontrolled infections not responsive to antibiotics, antiviral medicines, or
antifungal medicines.

5.2.9 Progressive malignant disease including post transplant lymphoproliferative disease.

5.2.10 Any secondary malignancy except basal and squamous cell carcinoma of the skin
within the past five years.

5.2.11 Nilotinib intolerance or hypersensitivity. 5.2.12 Impaired gastrointestinal (GI)
function or GI disease that may significantly alter the absorption of study drug (e.g.,
ulcerative diseases, uncontrolled nausea, vomiting, diarrhea, malabsorption syndrome,
small bowel resection or gastric bypass surgery).

5.2.13 Acute or chronic pancreatic disease 5.2.14 Major surgery within 4 weeks prior to
Day 1 of the study or who have not recovered from prior surgery.

5.2.15 Subject is pregnant, breast-feeding, or of childbearing potential without a
negative serum or urine pregnancy test within 7 days of enrollment. Male or female
patients of childbearing potential unwilling to use effective contraceptive precautions
throughout the trial.

5.2.16 Subject not willing to comply with treatment or response evaluation (including
associated procedures such as skin biopsy).

5.2.17 Subject has a concurrent illness which in the opinion of the investigator may
interfere with the treatment and evaluation of the patient.