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Restoration of Bowel Function After Laparoscopic Colorectal Surgery: Effect of Intravenous Lidocaine

Phase 2
18 Years
Not Enrolling
Colon Cancer, Inflammatory Bowel Diseases, Diverticulitis

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Trial Information

Restoration of Bowel Function After Laparoscopic Colorectal Surgery: Effect of Intravenous Lidocaine

The aim of this study is to assess whether perioperative intravenous lidocaine has an impact
on the early postoperative physical activity recovery of patients scheduled for laparoscopic
colorectal resection.

The study focuses on patients with colorectal disease, which receive the laparoscopic
(assisted) surgical approach.

It is hypothesized that in those patients receiving perioperative and post-operative
intravenous lidocaine, bowel function recovery will be faster, probably as a result of a
significant opioid sparing, less pain and attenuated inflammatory response.

Inclusion Criteria:

- scheduled to undergo laparoscopic colorectal resection

Exclusion Criteria:

- patients who have trouble to understand, read or communicate either in French or in

- dementia

- patients suffering from severe physical disability (arthritis, neuromuscular
dysfunction, stroke, paraplegia) or inability to walk or conduct daily activity

- patients suffering from severe cardiac or respiratory disease (status ASA IV

- patients suffering from metastatic carcinoma

- patients who have a history of chemoradiation within the six months preceding surgery

- allergy to lidocaine

- morbid obesity

- patients with chronic opioid use.

Type of Study:


Study Design:

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Outcomes Assessor), Primary Purpose: Supportive Care

Outcome Measure:

Restoration of bowel function

Outcome Time Frame:

72 hours after an operation

Safety Issue:


Principal Investigator

Mingkwan Wongyingsinn, Fellow

Investigator Role:

Principal Investigator

Investigator Affiliation:

McGill University Health Center


Canada: Ethics Review Committee

Study ID:




Start Date:

June 2009

Completion Date:

October 2011

Related Keywords:

  • Colon Cancer
  • Inflammatory Bowel Diseases
  • Diverticulitis
  • 60 patients scheduled to have a colorectal surgery
  • recruit at Montreal General Hospital
  • Colonic Neoplasms
  • Diverticulitis
  • Inflammatory Bowel Diseases
  • Intestinal Diseases