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Quality of Life in Patients After Combined Modality Treatment of Rectal Cancer

18 Years
85 Years
Open (Enrolling)
Rectal Cancer

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Trial Information

Quality of Life in Patients After Combined Modality Treatment of Rectal Cancer

Over the last two decades, rectal cancer research has lead to better understanding of
disease behaviour, resulting in more efficient treatments and higher prevalence of cancer
survivors.Due to aggressive therapy, rectal cancer survivors can exhibit late sequelae of
treatment, most common being impaired bowel, voiding, sexual malfunctioning and quality of
life impairment. In order to determine the impact of rectal cancer and its treatment on
patients' quality of life over time, this study will prospectively follow a cohort of
patients at specified intervals evaluating their physical symptoms, physical and social
functioning and overall quality of life.Medical and sociodemographic factors that might be
predictive will be tested.

Inclusion Criteria:

- histologically verified adenocarcinoma of the rectum,

- clinical stage II or III (IUCC TNM classification 2002);

- no prior radiotherapy and/or chemotherapy;

- World Health Organisation (WHO) performance status < 2;

- age at diagnosis of 18 or older;

- and adequate bone marrow, liver, renal and cardiac function (no history of ischemic
heart disease)

- mentally fit to complete questionnaires

Exclusion Criteria:

- a history of prior malignancy other than non-melanoma skin cancer or in situ
carcinoma of the cervix rendered the patient ineligible.

Type of Study:


Study Design:

Observational Model: Cohort, Time Perspective: Prospective

Outcome Measure:

To prospectively evaluate the quality of life of patients one year after rectal cancer resection

Outcome Time Frame:

one year after the operation

Safety Issue:



Slovenia: Ethics Committee

Study ID:




Start Date:

January 2008

Completion Date:

September 2012

Related Keywords:

  • Rectal Cancer
  • quality of life
  • rectal cancer
  • Rectal Neoplasms