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SCOR in Targeted Therapies for Infant Leukemia Project 3: Targeting FLT3 in Infant Leukemia


N/A
N/A
2 Years
Open (Enrolling)
Both
Leukemia

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Trial Information

SCOR in Targeted Therapies for Infant Leukemia Project 3: Targeting FLT3 in Infant Leukemia


OBJECTIVES:

- Determine the potential of lestaurtinib with or without chemotherapy agents in treating
samples from infants with leukemia.

- Determine whether FLT3 protein expression level and/or activation and sensitivity to
lestaurtinib differ between subgroups of infants with leukemia.

- Determine whether lestaurtinib activates STAT5, AKT, and RAS-MAPK and other pathways.

- Determine whether lestaurtinib can synergize with other chemotherapy agents kill infant
leukemia cells.

OUTLINE: This is a multicenter study.

Cryopreserved specimens are studied in vitro with lestaurtinib with or without chemotherapy
agents. Samples are analyzed for FLT3 protein expression and/or activation; sensitivity to
lestaurtinib with or without chemotherapy agents; and activation of STAT, AKT, and RAS-MAPK
and other pathways by western blot. The most effective treatment from this study is then
validated in vivo in a NOD/SCID xenograft model.

Inclusion Criteria


DISEASE CHARACTERISTICS:

- Cryopreserved samples from infants with leukemia available

PATIENT CHARACTERISTICS:

- Not specified

PRIOR CONCURRENT THERAPY:

- Not specified

Type of Study:

Observational

Study Design:

N/A

Outcome Measure:

Activity of lestaurtinib with and without chemotherapeutic agents

Safety Issue:

No

Principal Investigator

Patrick A. Brown, MD

Investigator Role:

Principal Investigator

Investigator Affiliation:

Sidney Kimmel Comprehensive Cancer Center

Authority:

United States: Federal Government

Study ID:

CDR0000675724

NCT ID:

NCT01150669

Start Date:

July 2010

Completion Date:

Related Keywords:

  • Leukemia
  • childhood acute lymphoblastic leukemia
  • childhood acute myeloid leukemia/other myeloid malignancies
  • Leukemia

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