A Phase II Study of Neoadjuvant Short Course Intensity Modulated Radiation Therapy (IMRT) for Patients With Rectal Cancer: An Analysis of Quality of Life and Biomarkers of Response
- Radiation treatment to the rectum will be given once a day, for 5 days. Each radiation
treatment will take about 20-30 minutes.
- The following procedures will be performed on day 1 of radiation treatment: physical
examination, blood tests and quality of life questionnaire.
- During radiation treatment a physical examination will be performed once during the 5
days of radiation treatment. A Quality of Life Questionnaire will be administered on
the last day of radiation treatment.
- Surgery will be performed within 3-14 days after the last day of radiation treatment.
Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
Bowel Quality of Life
To determine the rate of fecal incontinence at 1 year in patients undergoing an low anterior resection (LAR), as measured by bowel quality of life measure after preoperative conformal radiation therapy delivered in one week for rectal cancer.
Theodore S. Hong, MD
Massachusetts General Hosptial
United States: Institutional Review Board
|Massachusetts General Hospital||Boston, Massachusetts 02114-2617|