Physical Activity Benefits After Breast Cancer: Exploring Cytokine Mechanisms
Our previous research has shown that increases in physical activity can improve the health
and well-being of breast cancer survivors. The current study will determine whether the
physical activity increases are adequate for improved health by measuring physical activity
(accelerometer and self-report), muscle strength, fatigue, and sleep. Moreover, few studies
have examined cytokine changes in cancer survivors after participation in a physical
activity behavior change intervention with a mechanistic focus on cytokines which may
influence the muscle strength, fatigue, and sleep response to the intervention.
Seventy-four female, breast cancer survivors are being recruited within a 50-miles radius of
Springfield, IL. Participants will be in the study for approximately 5 months. Participants
will be asked to complete a questionnaire at the beginning of the study and 3 months later.
A blood sample will be drawn to determine serum cytokine levels.
Volunteers will be randomly assigned to 1 of 2 study groups. The intervention group will
participate in a 3 month physical activity intervention involving moderate intensity walking
and strength training with resistance bands.
This randomized controlled trial includes the following study aims:
Study aim 1: The intervention group will be compared with the control group to examine the
change in physical activity, muscle strength, fatigue, and sleep dysfunction before and
after participation in a physical activity intervention.
Study aim 2: To investigate mechanisms that may underlie the effects of the physical
activity intervention on muscle strength, fatigue, and sleep, we will compare the
intervention group with the control group in terms of changes in cytokine markers of
inflammation and evaluate whether such changes are consistent with and may mediate changes
in muscle strength, fatigue, and sleep dysfunction.
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Supportive Care
The intervention group will be compared with the control group to examine the change in physical activity, before and after participation in a physical activity intervention. Participants are in the study for approximately 5 months. Assessments will be conducted at baseline, and following the 3 month exercise intervention.
baseline and 3 months
Laura Q Rogers, MD, MPH
University of Alabama at Birmingham
United States: Institutional Review Board
|Southern Illinois University School of Medicine||Springfield, Illinois 62794-9658|