Genome Wide Association Study Evaluating Genetic Factors Related to the Efficacy and Tolerability of Fludarabine Treatment in Patients With CLL
- To identify genetic characteristics associated with the efficacy and toxicity of
fludarabine-based treatment in patients with chronic lymphocytic leukemia who
participated on E2997.
- To validate these genetic characteristics with a cancer cell model system to confirm
association and dissect the mechanism of effect.
OUTLINE: Archived DNA samples are analyzed for genetic characteristics associated with the
efficacy and toxicity to fludarabine-based treatment using Affymetrix 6.0 single nucleotide
polymorphism arrays. The results are then compared with data of genes identified in a cancer
cell model system, and with clinical data (response, toxicity, overall survival, and
progression-free survival) associated with each patient sample.
Association of single SNP genotype with overall and progression-free survival
Tait D. Shanafelt, MD