Crohn's disease and ulcerative colitis are chronic inflammatory disorders of the gut that
cause major life-long disability. Afflicting mostly young people at an age when they are
most active both in their private and professional life, inflammatory bowel disease (IBD)
represents an important public health problem affecting both the patients education, working
abilities, social life and quality of life. Previously a disease predominantly of the West,
there is now a marked increase in the incidence of IBD in Hong Kong. The cause of this
dramatic increase over the last decade is unknown. Genetic factors, environmental factors
and the gut bacteria may play a role in disease development. This study aims to explore the
factors that may be contributing to, or causing, the rise of IBD in Hong Kong. The
investigators propose to study the gut bacteria in Chinese patients with IBD compared with
non-IBD patients, and healthy relatives of IBD patients. IBD patients will be prospectively
recruited, blood samples will be obtained for serology and genotyping, stool samples and
biopsies will be collected during routine colonoscopy for microbiota analysis. Bloods, stool
and tissue gut microbiota from non-IBD patients will be collected for comparison. Studying
gut microbiota, genetics and environmental factors in populations with changing incidence of
IBD offers the greatest hope of identifying potentially important causative factors for
disease.
Observational
Observational Model: Case Control, Time Perspective: Prospective
To identify specific gut microbiota in IBD patients
Dominant species from colonic tissue and stool samples including bacteroides, bifidobacteria, firmucutes (using microarray analysis and pyrosequencing)
2 years
No
Siew C NG, PhD
Principal Investigator
Chinese University of Hong Kong
Hong Kong: Department of Health
IBD Microbe
NCT01140802
March 2010
Name | Location |
---|