Type of Study:

Observational

Study Design:

Observational Model: Case Control, Time Perspective: Prospective

Outcome Measure:

Evidence that cathepsin X influences on the eradication of Helicobacter pylori confirmed by lower expression of cathepsin X and cytokines in those patients. that can not eradicate Helicobacter pylori.

Outcome Description:

The investigators assume that vast majority of patients, that have problems with eradication of Helicobater pylori, not caused by primary resistence to antibiotics, can not eradicate helicobacter because of inappropriate immune response. The investigators will measure cathepsin X (CTSX) expression and assume that those patients who have low concentrations of CTSX also have inappropriate immune response seen in low levels of cytokines. To treat such patients, you need to give them different and longer antibiotic therapy.

Outcome Time Frame:

7 months after last participant included in the study

Safety Issue:

No

Principal Investigator

Alojz Ihan, MD, PhD

Investigator Role:

Study Director

Investigator Affiliation:

Institute of microbiology and immunology, Ljubljana, Slovenia

Authority:

Slovenia: Ethics Committee

Study ID:

IMI2010-1

NCT ID:

NCT01137942

Start Date:

November 2008

Completion Date:

July 2010

Related Keywords:

• Persistence of Infection With Helicobacter Pylori
• helicobacter pylori
• eradication failure
• Stomach Neoplasms