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Efficacy and Safety Assessment of Oral LBH589 in Adult Patients With Advanced Soft Tissue Sarcoma After Pre-treatment Failure: an Open-label, Multicenter Phase II Study

Phase 2
18 Years
Not Enrolling
Soft Tissue Sarcoma

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Trial Information

Efficacy and Safety Assessment of Oral LBH589 in Adult Patients With Advanced Soft Tissue Sarcoma After Pre-treatment Failure: an Open-label, Multicenter Phase II Study

Despite surgical excision and radiation therapy, approximately 50% of patients treated for
localised STS will experience local or distant relapse.

Recurrent STS : current therapeutic strategies Although some patients may be salvaged with
surgery, chemotherapy using doxorubicin-based regimens is in most cases indicated for
patients with recurrent STS. Progression-free survival (PFS) is in most cases less than or
equal to 6 months. Most patients die of their disease within 12-15 months following the
diagnosis of advanced disease. Doxorubicin is considered as the standard of care in the
first line setting for patients with locally advanced unresectable or metastatic STS.
However, only 15-25% of these patients exhibit objective response following this
chemotherapy while 30-35% experiment rapid disease progression. Doxorubicin-based
combinations have resulted in an inconsistent increase in response rate but no survival
advantage versus single-agent doxorubicin. After doxorubicin-based regimens failure, most
agents, including other agents approved for the treatment of STS such as dacarbazine,
ifosfamide and trabectedin, have shown very low response rates and short PFS. The only
approved agent in this setting is trabectedin, which has shown prolonged stabilization in
approximately 20% of patients at 6 months in several phase II trials. Gemcitabine-docetaxel
combination, although not approved for the treatment of STS has shown interesting response
rates in leiomyosarcomas, as well as other STS subtypes . Mechanisms of chemoresistance are
poorly understood.

Place of LBH589:

LBH589 is postulated to have activity in sarcomas by being able to arrest gene transcription
through the inhibition of HDAC, to cause the misfolding of important proteins for sarcoma
biology such as fusion proteins or overexpressed genes (HDM2, cdk4, AKT…) via the disruption
of HSP90 functioning . Some mechanisms similar to leukemia-associated fusion proteins, which
have been shown to recruit HDAC to repress hematopoietic differentiation, might be involved
by some translocation-associated sarcomas. The SYT portion of the synovial sarcoma
oncoprotein SYT-SSX interacts with trithorax-group proteins and binds directly to the mSin3A
HDAC component. SSX associates with polycomb-group proteins, which involve HDAC activity to
mediate transcriptional repression; thus, aberrant epigenetic changes in gene expression
seem to be a central effect of the fusion oncoprotein in this disease. HDAC inhibitors have
been effective against both synovial sarcoma and Ewing sarcoma in preclinical studies .
Evidence has also been presented for growth inhibition and induction of differentiation in
clear cell sarcoma (Nielsen TO, Vancouver Coastal Health Research Institute, Vancouver,
Canada, unpublished data) and chondrosarcoma by HDACi.

Data from the phase I study involving patients with advanced solid tumors indicate that the
MWF every week schedule of LBH589 is pharmacodynamically and clinically active. Histone
acetylation was detected in peripheral blood cells for up to 72 hours (the maximum duration
between doses on the MWF every week schedule) in 50% of patients at the 20 mg and 30 mg
doses and CR and PR were observed in two and three patients respectively, with cutaneous
T-cell lymphoma. Grade 3 fatigue was the dose-limiting toxicity (DLT) in 2 patients treated
at the 40 mg level and 1 patient treated at the 60 mg level. The 40 mg level seem to be
tolerable and is felt to be the most likely to have activity in solid tumors.

After first-line chemotherapy failure, efficacy of therapeutic alternatives is limited. The
purpose of this trial is therefore to investigate the efficacy, safety and tolerability of
40 mg of LBH589 given orally on a twice a week.

Inclusion Criteria


- Age ≥ 18 years.

- Histologically proven advanced metastatic or unresectable soft tissue sarcoma,
excluding osteosarcoma.

- Prior treatment with a doxorubicin containing regimen whether in the adjuvant setting
or for metastatic/advanced disease. If doxorubicin was given as adjuvant therapy
patient may be included if relapse occurs within a year of adjuvant therapy. If
relapse occurs more than one year after the completion of adjuvant therapy, the
patient must have received one prior regimen for metastatic disease. Patient may have
received one or more previous line of therapy. Patients with sex cord tumors may be
included after prior treatment with a platinum containing regimen (pretreatment with
a doxorubicin containing regimen is not required for this patients subgroup).

- Patient has at least one site of measurable nodal disease at baseline ≥ 2.0 cm in the
longest transverse diameter and clearly measurable in at least two perpendicular
dimensions, as determined by CT scan (MRI is allowed only if CT scan can not be

- ECOG performance status (PS) ≤ 2.

- Adequate haematological, liver and renal function:

- Absolute Neutrophil Count (ANC) ≥ 1.5 G/L,

- Hemoglobin ≥ 9 g/dL,

- Platelets ≥ 100 G/L,

- Total calcium (corrected for serum albumin) ≥ lower limit of normal (LLN) or
correctable with supplements,

- Magnesium ≥ LLN or correctable with supplements,

- Potassium ≥ LLN or correctable with supplements,

- Phosphorus ≥ LLN or correctable with supplements,

- Aspartate Aminotransferase (AST) and Alanine Aminotransferase (ALT) ≤ 2.5 x
upper limit of normal (ULN) (or ≤ 5.0 x ULN if liver metastasis are present),

- Serum bilirubin ≤ 1.5 x ULN,

- Serum creatinine ≤ 1.5 x ULN,

- If the serum creatinine is ≥ 1.5 x ULN, then a 24-hour creatinine clearance must
be conducted and the result must be ≥ 50 mL/min.

- Clinical euthyroidy (patients are permitted to receive thyroid hormone supplements to
treat underlying hypothyroidism).

- Ability to swallow capsules or tablets.

- Life expectancy ≥ 12 weeks.

- Mandatory affiliation with health security insurance.

- Signed written informed consent.


- Prior treatment with any HDAC or HSP90 inhibitor drug.

- Unresolved toxicities (≥ Grade 1) from prior therapy that would, in the opinion of
the investigator, compromise patient safety.

- Any of the following concurrent severe and/or uncontrolled medical conditions which
could compromise participation in the study:

- Impaired cardiac function or clinically significant cardiac diseases, including
any one of the following:

- Left ventricular systolic function (LVEF) determined by MUGA scan or
echocardiogram < center normal value,

- Complete left bundle branch block,

- Obligate use of a cardiac pacemaker,

- Congenital long QT syndrome,

- History or presence of ventricular tachyarrhythmia,

- Presence of unstable atrial fibrillation (ventricular response > 100bpm),

- Clinically significant resting bradycardia (< 50 bpm),

- Mean corrected QT interval (QTcF - n ≥ 3) ≥ 450 msec on screening ECG,

- Right bundle branch block + left anterior hemiblock (bifasicular block),

- Angina pectoris ≤ 3 months prior to starting study drug,

- Acute myocardial infarction (MI) ≤ 3 months prior to starting study drug,

- History or presence of acute coronary syndrome,

- Other clinically significant heart disease (e.g.: Congestive heart failure
(CHF), uncontrolled hypertension, history of labile hypertension, or
history of poor compliance with an antihypertensive regimen),

- Impaired gastrointestinal (GI) function or GI disease that may significantly
alter the absorption of LBH589 (e.g.: ulcerative diseases, uncontrolled nausea,
vomiting, diarrhea, malabsorption syndrome, or extensive small bowel resection),

- Other concurrent severe and/or uncontrolled medical conditions (e.g.:
uncontrolled diabetes, active or uncontrolled infection, chronic obstructive or
chronic restrictive pulmonary disease) that could cause unacceptable safety
risks or compromise compliance with the protocol.

- Current treatment with any of the medications listed in appendix 04, if the treatment
cannot be discontinued or switched to a different medication prior to starting study
drug. The medications listed in appendix 04 have a relative risk of prolonging the QT
interval, or inducing Torsades de Pointes, or inhibit CYP3A4/5.

- Major surgery ≤ 2 weeks prior starting study drug or who have not recovered from side
effects of such therapy.

- History of brain metastases.

- Absence of at least one metastatic lesion greater than or equal to 2cm on
pretreatment CT scan or other radiographic imaging as defined in RECIST criteria
(appendix 02).

- Systemic treatment with any anti-cancer drug, including any investigational drug that
is administered on an intermittent schedule if the last dose has not been
administered ≥ 4 weeks ago, or if the patient has not recovered from any ongoing
toxicity prior to study enrolment.

- Systemic treatment with any anti-cancer drug, including investigational drug that is
administered on a chronic dosing schedule (e.g.: daily dosing, every-other-day
dosing, MWF weekly) if ≤ 5 half-lives elapsed since the last dose, or if the patient
has not recovered from any ongoing toxicity prior to study enrolment.

- Women who are pregnant or breast feeding.

- Women of childbearing potential (WCBP) are excluded unless they have a negative serum
pregnancy test ≤ 48 hours prior starting study treatment. All sexually active WCBP
and male patients are excluded unless they agree to use adequate contraceptive
methods (injectable or implantable hormonal contraceptive, tubal ligation,
intra-uterine device, barrier contraceptive with spermacide, or vasectomized partner)
throughout the study. Since the potential of LBH589 to induce CYP3A4 is unknown,
patients who are using oral contraceptives should use another effective method of

- Current immunosuppressive syndrome.

- History of another malignancy that is currently clinically significant or currently
requires active intervention.

- Refusal or inability to comply with the protocol or follow the instructions given to
them by the clinic staff.

Type of Study:


Study Design:

Allocation: Non-Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Outcome Measure:

3 months non progression rate

Outcome Time Frame:

3 months

Safety Issue:


Principal Investigator

BLAY PR Jean-Yves

Investigator Role:

Principal Investigator

Investigator Affiliation:

Centre Léon Berard


France: Afssaps - Agence française de sécurité sanitaire des produits de santé (Saint-Denis)

Study ID:




Start Date:

January 2010

Completion Date:

January 2013

Related Keywords:

  • Soft Tissue Sarcoma
  • Sarcoma
  • Safety
  • Efficacy
  • Sarcoma