Know Cancer

or
forgot password

Role of Inflammation in PML


N/A
18 Years
N/A
Open (Enrolling by invite only)
Both
Progressive Multifocal Leukoencephalopathy

Thank you

Trial Information

Role of Inflammation in PML


To determine precisely what are the host or viral factors that may predict a favorable
outcome for PML patients and the role of inflammation in preventing JCV from causing brain
disease. One of the goals of this study is to help establish non-invasive markers of PML
evolution by studying the brain metabolism in PML lesions using Magnetic Resonance Imaging
(MRI), Magnetic Spectroscopy (MRS) and other advanced imaging modalities.


Inclusion Criteria:



- PML patients of 18 years of age or older will be included in this study.

Exclusion Criteria:

1. Presence of opportunistic brain lesions other than PML. ( e.g., toxoplasmosis,
lymphoma)

2. Presence of confounding neurological disorder such as brain neoplasm etc.

In addition patients with a contraindication to MRI examination will be excluded from
study. Contraindications to the MRI examination include:

1. Medically unstable or hematological, renal, or hepatic dysfunction.

2. Cardiac pacemaker

3. Internal clips,

4. Metal implants, or external clips with 10 mm of the head.

5. Metal in the eyes.

6. Pregnant

7. Claustrophobia

Type of Study:

Observational

Study Design:

Observational Model: Case Control, Time Perspective: Prospective

Principal Investigator

Igor J Koralnik, MD

Investigator Role:

Principal Investigator

Investigator Affiliation:

Beth Israel Deaconess Medical Center

Authority:

United States: Institutional Review Board

Study ID:

2004-P-000089

NCT ID:

NCT01132053

Start Date:

June 2004

Completion Date:

September 2013

Related Keywords:

  • Progressive Multifocal Leukoencephalopathy
  • JCV
  • Inflammation
  • Leukoencephalopathy, Progressive Multifocal
  • Leukoencephalopathies

Name

Location
Beth Israel Deaconess Medical Center Boston, Massachusetts  02215