Gene Expression Profiling Using Paraffin-embedded Tissues and the Nuclease Protection Assay in Diffuse Large B-cell Lymphoma (DLBCL) Treated With CHOP or R-CHOP: An ECOG and SWOG Correlative Study of E4494
- To identify genes predictive of clinical outcome (failure-free survival and overall
survival) among patients with diffuse large B-cell lymphoma treated with CHOP or R-CHOP
induction on ECOG-E4494 using the nuclease protection assay for measuring gene
expression in paraffin-embedded tissue.
- To identify genes that change their prognostic profile with the addition of rituximab
to CHOP chemotherapy.
OUTLINE: This is a multicenter study.
Unstained formalin-fixed, paraffin-embedded samples are analyzed for gene expression via
nuclease protection assay.
Identification of genes predictive of clinical outcome
Jane N. Winter, MD
Robert H. Lurie Cancer Center