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Gene Expression Profiling Using Paraffin-embedded Tissues and the Nuclease Protection Assay in Diffuse Large B-cell Lymphoma (DLBCL) Treated With CHOP or R-CHOP: An ECOG and SWOG Correlative Study of E4494


N/A
60 Years
N/A
Not Enrolling
Both
Lymphoma

Thank you

Trial Information

Gene Expression Profiling Using Paraffin-embedded Tissues and the Nuclease Protection Assay in Diffuse Large B-cell Lymphoma (DLBCL) Treated With CHOP or R-CHOP: An ECOG and SWOG Correlative Study of E4494


OBJECTIVES:

- To identify genes predictive of clinical outcome (failure-free survival and overall
survival) among patients with diffuse large B-cell lymphoma treated with CHOP or R-CHOP
induction on ECOG-E4494 using the nuclease protection assay for measuring gene
expression in paraffin-embedded tissue.

- To identify genes that change their prognostic profile with the addition of rituximab
to CHOP chemotherapy.

OUTLINE: This is a multicenter study.

Unstained formalin-fixed, paraffin-embedded samples are analyzed for gene expression via
nuclease protection assay.

Inclusion Criteria


DISEASE CHARACTERISTICS:

- Diagnosis of diffuse large B-cell lymphoma

- Treated with CHOP or R-CHOP on ECOG-E4494

PATIENT CHARACTERISTICS:

- Not specified

PRIOR CONCURRENT THERAPY:

- See Disease Characteristics

Type of Study:

Observational

Study Design:

N/A

Outcome Measure:

Identification of genes predictive of clinical outcome

Safety Issue:

No

Principal Investigator

Jane N. Winter, MD

Investigator Role:

Principal Investigator

Investigator Affiliation:

Robert H. Lurie Cancer Center

Authority:

Unspecified

Study ID:

CDR0000671515

NCT ID:

NCT01131208

Start Date:

July 2010

Completion Date:

Related Keywords:

  • Lymphoma
  • contiguous stage II adult diffuse large cell lymphoma
  • noncontiguous stage II adult diffuse large cell lymphoma
  • recurrent adult diffuse large cell lymphoma
  • stage I adult diffuse large cell lymphoma
  • stage III adult diffuse large cell lymphoma
  • stage IV adult diffuse large cell lymphoma
  • Lymphoma
  • Lymphoma, B-Cell
  • Lymphoma, Large B-Cell, Diffuse

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