Inclusion Criteria

- INCLUSION CRITERIA:

- Diagnosis of advanced RCC associated with HLRCC (cohort 1) or sporadic/non-HLRCC
papillary RCC (cohort 2)

- Measurable disease, defined as at least one lesion that can be accurately measured in
at least one dimension (longest diameter to be recorded) as greater than or equal to
20 mm with conventional techniques or as greater than or equal to 10 mm with spiral
CT scan.

- No more than two prior regimens targeting the VEGF pathway; no prior bevacizumab
therapy

- Age greater than or equal to 18 years.

- Performance status ECOG 0-2

- Patients must have normal organ and marrow function as defined below: WBC count
greater than or equal to 3,000/microL, absolute neutrophil count greater than or
equal to 1,500/microL, platelet count greater than or equal to 100,000/microL, serum
creatinine greater than or equal to 2 times the upper limit of reference range or
creatinine clearance greater than or equal to 30 ml/min, AST and ALT less than 2.5
times the upper limit of reference range, total bilirubin less than 1.5 times the
upper limit of reference range ( less than 3 x upper limit of reference range in
patients with Gilbert's disease), alkaline phosphatase less than or equal to 2.5
times the upper limit of reference range (or less than than or equal to 5 times the
upper limit of reference range if considered to be related to liver or bone
metastases by the PI)

- Recovery from acute toxicity of prior treatment for RCC (to less than or equal to
grade 1 the active version of CTCAE or to a level permitted under other sections of
Inclusion/ Exclusion criteria).

- At least 4 weeks from completion of major surgery and a healed surgical incision

- Negative pregnancy test (within 7 days of enrolment) in women of childbearing
potential

- No myocardial infarction, GI perforation/fistula, intraabdominal abscess,
cerebrovascular accidents within six months prior to study entry

- No coagulopathy or bleeding diathesis

- Ability to understand and the willingness to sign a written informed consent
document.

EXCLUSION CRITERIA:

- Prior invasive malignancy of other histology, with the exception of adequately
treated basal or squamous cell carcinoma of the skin, or any other malignancy for
which the patient has not required treatment for three years.

- Patients with known brain metastases unless treated with an appropriate modality with
no evidence of progression/recurrence for greater than 3 months

- Hypertension not controlled by medical therapy (resting systolic blood pressure
greater than 140 mmHg or diastolic blood pressure greater than 90 mmHg on at least
two occasions over a 24 hour period despite optimal medical management).

- Uncontrolled intercurrent illness including, but not limited to, ongoing or active
infection requiring intravenous antibiotics, symptomatic congestive heart failure
(New York Heart Association grade III or greater), unstable angina pectoris, or
psychiatric illness/social situations that would limit compliance with study
requirements.

- Serious, non-healing wound or ulcer; bone fracture within 3 months prior to study
entry

- Patient known to be HIV-positive and requiring antiretroviral therapy (due to the
risk of potential drug interactions)

- Concomitant therapy with potent inhibitors of CYP450 3A4 (e.g. ketoconazole,
verapamil etc) or with potent CYP450 1A2 inhibitors (fluoroquinolone antibiotics
including ciprofloxacin, levofloxacin, and norfloxacin; ticlodipine, cimetidine,
amiodarone,etc. see Appendix C)

- Pregnant women are excluded from this study because bevacizumab and erlotinib are
anti-cancer agents with the potential for teratogenic or abortifacient effects.
Because there is an unknown but potential risk for adverse events in nursing infants
secondary to treatment of the mother with these agents, breastfeeding should be
discontinued if the mother is treated on this study

- All men and women of childbearing potential must be willing to use effective
contraception as determined by the principal investigator (including but not limited
to abstinence, hormonal contraceptives (birth control pills, injections, or
implants), intrauterine device (IUD), tubal ligation, vasectomy) from the time of
enrolment to at least six months following the last dose of drug

- Any known hypersensitivity to bevacizumab, erlotinib or other excipients of these
drugs

- Documented baseline proteinuria greater than 1000mg/day on 24 hour urine collection.
Only patients with 1+ or greater proteinuria on UA and a spot urine
protein:creatinine ratio of greater than 0.5 will undergo a 24 hour urine collection
for quantitation of proteinuria.

- Left ventricular ejection fraction less than 40% as measured on transthoracic
echocardiogram.