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Validation of a Multi-gene Test for Lung Cancer Risk

50 Years
90 Years
Open (Enrolling)
Lung Cancer

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Trial Information

Validation of a Multi-gene Test for Lung Cancer Risk

Because more than 160,000 individuals die of lung cancer/year in the United States alone, it
is important to use the best possible methods to determine whether increased surveillance of
individuals at highest risk for lung cancer will result in reduced lung cancer mortality.
The Lung Cancer Risk Test (LCRT) proposed for evaluation promises to accurately identify the
10-15% of the population that is most susceptible to lung cancer based on genetic
predisposition. More than 90 million individuals in the United States alone are
demographically at high risk for lung cancer and potential candidates for increased

Inclusion Criteria:

- 20 or more pack year smoking history

- clinical need for diagnostic bronchoscopy

Exclusion Criteria:

- Lung Cancer within 3 months after the date of enrollment

Type of Study:


Study Design:

Observational Model: Case-Only, Time Perspective: Prospective

Principal Investigator

James Willey, MD

Investigator Role:

Principal Investigator

Investigator Affiliation:

University of Toledo Health Science Campus


United States: Food and Drug Administration

Study ID:

UTHSC - 11



Start Date:

May 2011

Completion Date:

September 2015

Related Keywords:

  • Lung Cancer
  • Lung Cancer
  • Lung Neoplasms



University of Michigan Ann Arbor, Michigan  48109-0624
Cleveland Clinic Foundation Cleveland, Ohio  44195
Mayo Clinic Rochester, Minnesota  55905
Medical University of South Carolina Charleston, South Carolina  29425-0721
Inova Fairfax Hospital Falls Church, Virginia  22042-3300
Ohio State University Columbus, Ohio  43210
The Toledo Hospital Toledo, Ohio  43606
Vanderbilt Nashville, Tennessee  37212
National Jewish Health Denver, Colorado  80206
Henry Ford Detroit, Michigan  48202
University of Toledo, Health Science Campus Toledo, Ohio  43614
Mercy St. Vincent Medical Center Toledo, Ohio  43608
Tennessee Valley Veterans Admin. Nashville, Tennessee  37232