Trial Information

Frequency of Methods of Local Invasion of Pancreatic Adenocarcinoma

Pancreatic cancer is the eighth most common malignancy, and the fifth leading cause of
cancer-related death, in the United States. Unfortunately, patients often present late in
the course of the disease. Accordingly, the 1- year survival rate is approximately 20%, and
the 5-year survival rate is less than 4%. Even in patients with local disease who are
surgical candidates, survival at five years remains only 10-25%. Staging for pancreatic
adenocarcinoma typically utilizes the TNM classification, where "T" represents tumor size,
"N" represents regional lymph node metastasis, and "M" represents distant metastasis. This
type of staging can usually only be done after operative resection. Unfortunately, up to 25%
of patients are found to be unresectable at the time of surgical exploration. This is most
often due to local invasion or metastatic disease. Local microscopic invasion is associated
with recurrence of pancreatic cancer after pancreatic resection. Comprehensive data on the
patterns of local invasion by pancreatic cancer have not been published. We believe that it
would be beneficial to investigate the frequency of the various methods of local invasion of
pancreatic adenocarcinoma. A clearer understanding of the natural history of local invasion
could potentially lead to a better determination of what constitutes unresectability.