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Frequency of Methods of Local Invasion of Pancreatic Adenocarcinoma

18 Years
85 Years
Open (Enrolling)
Pancreatic Cancer

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Trial Information

Frequency of Methods of Local Invasion of Pancreatic Adenocarcinoma

Pancreatic cancer is the eighth most common malignancy, and the fifth leading cause of
cancer-related death, in the United States. Unfortunately, patients often present late in
the course of the disease. Accordingly, the 1- year survival rate is approximately 20%, and
the 5-year survival rate is less than 4%. Even in patients with local disease who are
surgical candidates, survival at five years remains only 10-25%. Staging for pancreatic
adenocarcinoma typically utilizes the TNM classification, where "T" represents tumor size,
"N" represents regional lymph node metastasis, and "M" represents distant metastasis. This
type of staging can usually only be done after operative resection. Unfortunately, up to 25%
of patients are found to be unresectable at the time of surgical exploration. This is most
often due to local invasion or metastatic disease. Local microscopic invasion is associated
with recurrence of pancreatic cancer after pancreatic resection. Comprehensive data on the
patterns of local invasion by pancreatic cancer have not been published. We believe that it
would be beneficial to investigate the frequency of the various methods of local invasion of
pancreatic adenocarcinoma. A clearer understanding of the natural history of local invasion
could potentially lead to a better determination of what constitutes unresectability.

Inclusion Criteria:

- Tissue confirmed diagnosis of pancreatic adenocarcinoma.

- Underwent surgical resection for adenocarcinoma at the Columbia University Medical
Center between 2001-2009.

Exclusion Criteria:

- Did not undergo surgery

Type of Study:


Study Design:

Observational Model: Cohort, Time Perspective: Retrospective

Outcome Measure:

Primary outcome: Frequency of local invasion modalities in surgical population

Outcome Description:

We will review the clinical and pathology information from the CUMC surgical database to determine the frequency of the various modalities of local invasion of pancreatic adenocarcinoma. This includes: peripancreatic fat invasion, neural/perineural invasion, vascular invasion, macrovascular invasion, duodenal invasion, bile duct invasion, splenic invasion,and gastric invasion.

Outcome Time Frame:

1 year

Safety Issue:


Principal Investigator

Wendy K Chung, MD

Investigator Role:

Principal Investigator

Investigator Affiliation:

Columbia University


United States: Institutional Review Board

Study ID:




Start Date:

September 2008

Completion Date:

July 2013

Related Keywords:

  • Pancreatic Cancer
  • Pancreatic adenocarcinoma
  • Local invasion by pancreatic adenocarcinoma
  • Recurrence of pancreatic cancer
  • Surgical resection of pancreatic cancer
  • Adenocarcinoma
  • Adenocarcinoma, Mucinous
  • Pancreatic Neoplasms



Columbia University Medical Center New York, New York  10032