Inclusion Criteria:

- histologically confirmed small-cell lung cancer

- limited disease status

- with evaluable disease

- 18 years or older

- ECOG performance status 0,1,2

- expected survival time should be 12 weeks or longer

- Adequate organ function as evidenced by the following; Absolute neutrophil count >
1.5 x 109/L; platelets > 100 x 109/L; total bilirubin ≤1.5 UNL; AST and/or ALT < 5
UNL; creatinine clearance ≥ 50mL/min

- Written informed consent form

Exclusion Criteria:

1. Uncontrolled systemic illness such as DM, CHF, unstable angina, hypertension or
arrhythmia

2. Patients with active infection requiring antibiotics

3. Pregnant or nursing women ( Women of reproductive potential have to agree to use an
effective contraceptive method)

4. Prior history of malignancy within 5 years from study entry except for a adequately
treated basal cell or squamous cell skin cancer or in situ cervical cancer,
well-treated thyroid cancer

5. previous history of chemotherapy or radiotherapy