Trial Information

Evaluation of Chest Pain, Effectiveness and Safety of Pleurodesis With Pleural Catheters and Silver Nitrate for Malignant Pleural Effusion.

Malignant pleural effusion is a frequent complication in advanced neoplasia. Pleurodesis is
the procedure of choice for symptomatic control, with talc as the sclerosing agent of
choice. However, the occurrence of severe adverse effects associated with its use has led to
the search for other agents.

Silver nitrate poses an option, presenting excellent results in animal models and having
successful usage in pleurodesis in the past. Although important, the current literature on
the effective use of silver nitrate for pleurodesis is still too scarce, and a deeper
knowledge on the occurrence of adverse side effects, especially pain, is still necessary to
allow the substance to be considered as an effective alternative to talc, as well as for the
definition of an adequate dosage.