(COPD History Assessment In SpaiN): "Estudio Sobre la Evolución Multidimensional de la Enfermedad Pulmonar Obstructiva Crónica (EPOC)".
Observational studies are needed to ascertain the natural history and progression of COPD,
and to better define its phenotypes. These two aspects are considered fundamental to a
proper evaluation of current (and future) COPD treatment options, and it could possibly
justify the limited impact of recent major drug trials.
Currently, there remain gaps in the natural history of patients with COPD. Most data are
from analysis of mild COPD patients or smokers, usually measuring only fall in FEV1, and
both have significant limitations in design and interpretation.
Studies in more severe patients with COPD have also been conducted mainly by studying lung
function, possibly influenced by the recommendations of current guidelines for disease
management. In recent years, we have more longitudinal data on changes in exercise capacity,
imaging, and biomarkers, among other variables of interest, but our knowledge is yet
The research project CHAIN (COPD Assessment History in Spain): "A Multidimensional Study on
the Evolution of Chronic Obstructive Pulmonary Disease (COPD) is a multicenter observational
study that will follow prospectively two cohorts: a) a COPD group active or former smokers
(COPD cohort) and b) a group of active smokers or former smokers without COPD (control
cohort). Both cohorts will be followed up for a period of at least 5 years, with visits
every 12 months (and phone controls at least every 6 months). We will try to extend the
monitoring of the cohort up to 10 years. CHAIN is supported by the PII of COPD SEPAR
Observational Model: Cohort, Time Perspective: Prospective
To better determine COPD with a multidimensional assessment and the phenotypic progression of COPD
Ciro Casanova, MD
Hospital Nuestra Señora de la Candelaria
Spain: Comité Ético de Investigación Clínica