Inclusion Criteria:

- Histologically confirmed locally advanced prostatic cancer : T3 or T4 or pT3 (on
biopsy), N0, M0

- Patient whose prostatic cancer has never been treated (excepted transurethral
resection for obstructive syndrom)

- Karnofsky > or = 70

- Age < 80 years old

- Life expectancy > 7 years

- Informed consent given by the patient

- No abnormal transaminases (> or = 3* normal values) on a recent sample (< 2 months)

Exclusion Criteria:

- Patient who could not understand the information regarding the study and give his
informed written consent, or patient who has refused to sign the informed consent
sheet,

- Patient who could not respect the conditions of the protocol,

- Patient who has already received a previous treatment for his prostate cancer,
excepted transurethral resection for obstructive syndrom,

- Patient who has been surgically castrated or with a medical history of bilateral
suprarenalectomy or hypophysectomy,

- Patient who had another cancer during the 5 last years excepted a basal cell
carcinoma or a carcinoma in situ (excepted bladder),

- Patient with a ganglionic or metastatic prostate cancer extension suspected on exams,

- Patient with a serious and unstable pathology,

- Patient who could not receive a prostatic external irradiation,

- Patient receiving or who has received another experimental treatment during the 3
last months,

- Patient with a hepatic insufficiency or abnormal transaminases (> or = 3* normal
values).