Inclusion Criteria:

- Histopathologically confirmed newly diagnosed glioblastoma multiforme. Diagnosis
must be made by surgical biopsy or excision

- The tumor must be supratentorial in location

- The planning target volume (tumor plus margin) must measure <= 150 cm^3 in volume

- Age >=18 years

- Life expectancy of at least 12 weeks

- Patient must have adequate organ function to tolerate temozolomide (details in the
protocol)

Exclusion Criteria:

- Patients who have previously been treated with brain irradiation to the region that
would result in overlap of the radiation fields

- Tumor foci detected below the tentorium

- Multifocal disease or leptomeningeal spread

- Prior allergic reaction to the study drugs involved in this protocol

- Patients with pacemaker will be allowed to undergo CT instead of MRI

- Pediatric patients (age <18), pregnant women, and nursing patients will be excluded