Inclusion Criteria

Inclusion Criteria

- Age ≥ 18 years on the date of consent.

- ECOG performance status of 0 or 1.

- Histological or cytological diagnosis of adenocarcinoma of the prostate.

- Metastatic disease on chest, abdominal, or pelvic CT and/or bone scan for which no
curative therapy exists.

- Progression of prostate cancer. Progression is defined by one or more of the
following:

1. Increasing serum PSA level: two consecutive increases in PSA levels documented
over a previous reference value obtained at least one week apart. If the third
PSA value is less than the second, an additional fourth test to confirm a rising
PSA is acceptable. The last confirmation PSA value must be obtained within the
14 days prior to randomization. A minimum starting value of 2.0 ng/mL is
required for study randomization.

2. Progressive measurable disease: at least a 20% increase in the sum of the
diameters of measurable lesions over the smallest sum observed or the appearance
of one or more new lesions as assessed by CT scan. Measurable lesions are nodal
or visceral soft-tissue lesions with nodal lesions ≥ 15 mm in diameter at the
shortest axis and visceral/soft-tissue lesions ≥ 10 mm in longest diameter (See
Section 6.4).

3. Bone Progression: appearance of 2 or more new lesions on bone scan (or other
imaging).

- All patients who have not had a surgical orchiectomy must continue treatment with
LHRH agonist or antagonist to maintain a castrate level of testosterone.

- Patient must fulfill "Prior Therapy" criteria as follows:

1. Chemotherapy: No prior chemotherapy for metastatic disease is permissible.
(Exception: neoadjuvant/adjuvant chemotherapy if received > 12 months prior to
randomization.)

2. Hormone therapy: prior surgical or medical castration therapy is required. Prior
treatment with non-steroidal antiandrogens, abiraterone or other experimental
hormone therapy (e.g. MDV3100, YAK-700) is allowed provided a minimum of at
least 14 days have passed since completing therapy and randomization in the
study.

3. Experimental therapy: prior non-cytotoxic experimental therapy is permitted
provided a minimum of at least 14 days has passed since completing therapy prior
to randomization.

4. Radiation: prior external beam radiation is permitted provided a minimum of at
least 28 days have passed since completing radiotherapy at the time of
randomization (or following disease progression and prior to receiving therapy
at the time of cross-over). Exception for radiotherapy: at least 7 days must
have passed since completing single fraction of ≤ 800 cGy.

5. Corticosteroids: prior corticosteroid therapy is permitted. Within 4 days
following randomization, all patients must be taking prednisone 5 mg BID.

- Baseline laboratory values as stated below:

1. ANC ≥ 1.5 x 109 cells /L, platelet count ≥ .100 x 109 /L, and hemoglobin ≥ 9
g/dL without transfusion.

2. Creatinine ≤ 1.5 x upper limit of normal (ULN).

3. Total bilirubin ≤ 1.1 x ULN (unless elevated secondary to conditions such as
Gilbert's disease).

4. SGPT (ALT) and SGOT (AST) ≤ 2.5 x ULN.

5. Castrate serum testosterone level (< 50 ng/dL-or-< 1.7 nmol/L).

- Recovery from all toxicities of prior therapy to ≤ grade 2 by NCI CTCAE, version 3.0.
(Exception: any toxicity that in the view of the Investigator is not a clinically
significant safety risk for further therapy administration, including, but not
limited to: anemia, fatigue, erectile dysfunction, hot flashes, lymphedema of an
extremity, dizziness, cough, and urinary incontinence).

- Must be willing to use effective contraception, if of child bearing potential,
throughout study treatment and for 3 months after completion of study treatment.

- Must be willing not to change (add or subtract) bone protecting therapy
(bisphosphonates and/or denosumab) during the study unless changed for toxicity.

- Written informed consent must be obtained prior to any protocol-specific procedures
being performed.

Exclusion Criteria

- Unable to tolerate a dose of 10 mg of prednisone a day.

- Requiring an amount of opioids to control pain > 30 mg of a morphine-equivalent per
day.

- Known coagulopathy or actively receiving warfarin (Coumadin) therapy.

- Documented brain metastases, or carcinomatous meningitis, treated or untreated (Brain
imaging for asymptomatic patients is not required).

- Current symptomatic cord compression requiring surgery or radiation therapy (once
successfully treated and there has been no progression, patients are eligible for the
study).

- Active second malignancy (except adequately treated non-melanomatous skin cancer or
other solid tumors curatively treated with no evidence of disease > 3 years).

- History of allergic reactions to therapeutic antisense oligonucleotides.

- Uncontrolled medical conditions such as heart failure, myocardial infarction,
uncontrolled hypertension, stroke or treatment of a major active infection within 3
months of randomization, as well as any significant concurrent medical illness that
in the opinion of the Investigator would preclude protocol therapy.

- Planned concomitant participation in another clinical trial of an experimental agent,
vaccine, or device. Concomitant participation in observational studies is acceptable.