Liposome-encapsulated Doxorubicin (Myocet) Plus Cyclophosphamide as First or Second Line Therapy for Older Patients With Metastatic Breast Cancer
Elderly individuals make up a large part of the breast cancer population. When treated with
chemotherapy for metastatic disease they derive similar benefits to their younger
counterparts. Anthracyclines are associated with a cumulative dose-dependent cardiomyopathy
with increased rate in patients over the age of 70. Liposomal-encapsulated doxorubicin
improves the therapeutic index of doxorubicin by reducing significantly the cardiotoxicity
and grade 4 neutropenia and provides comparable antitumor efficacy, when used in combination
with cyclophosphamide as first-line therapy for metastatic breast cancer
Interventional
Allocation: Non-Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
Overall Response Rate
Objective responses confirmed by CT or MRI every 3 months
No
Dimitris Mavrudis, MD
Principal Investigator
University Hospital of Crete
Greece: National Organization of Medicines
CT/08.32
NCT01120171
September 2009
March 2013
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