Micro RNA's Associated With Lymph Node Metastasis in Endometrial Cancer
N/A
N/A
N/A
N/A
N/A
Not Enrolling
Female
Endometrial Cancer
Female
Endometrial Cancer
Trial Information
Micro RNA's Associated With Lymph Node Metastasis in Endometrial Cancer
OBJECTIVES:
- To identify microRNA expression patterns associated with lymph node metastasis in
samples from patients with endometrial cancer.
OUTLINE: Banked tumor tissue specimens are analyzed for microRNA expression profiling by
microarray analysis and reverse transcriptase-PCR assays.
Inclusion Criteria
DISEASE CHARACTERISTICS:
- Histologically confirmed endometrioid endometrial cancer
- Stage IA, IB, IC, or IIIC disease
- Any grade
- Enrolled and evaluated on GOG-0210 Molecular Staging Study of Endometrial Cancer
- Consented to allow their specimens and clinical data to be collected and stored
for future research
- Underwent complete surgical staging, including the following:
- Hysterectomy
- Bilateral oophorectomy
- Washings as well as pelvic lymphadenectomy (sampling of four left and four right
pelvic lymph nodes)
- Para-aortic lymphadenectomy (sampling of one left and one right para-aortic
lymph node)
- Sufficient high-quality frozen primary tumor for testing with ≥ 75% tumor cellularity
and ≤ 10% necrosis
PATIENT CHARACTERISTICS:
- Not specified
PRIOR CONCURRENT THERAPY:
- See Disease Characteristics
Type of Study:
Observational
Study Design:
N/A
Outcome Measure:
Association between microRNA expression and lymph node metastasis
Safety Issue:
No
Principal Investigator
David S. Miller, MD
Investigator Role:
Principal Investigator
Investigator Affiliation:
Simmons Cancer Center
Authority:
Unspecified
Study ID:
CDR0000672415
NCT ID:
NCT01119573
Start Date:
May 2010
Completion Date:
Related Keywords:
- Endometrial Cancer
- stage I endometrial carcinoma
- stage III endometrial carcinoma
- Endometrial Neoplasms
- Sarcoma, Endometrial Stromal
- Adenoma
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