Inclusion Criteria:

- 18 years

- Patients with advanced, histologically or cytologically confirmed solid tumors,
malignant lymphomas, or multiple myeloma refractory to any standard therapy

- Radiographical, hematological or clinically evaluable tumor

- ECOG Performance Status of 0-2

- Life expectancy of at least 12 weeks

- Adequate bone marrow, liver, and renal function as assessed by the following
laboratory requirements:

- Total bilirubin less than or equal to 1.5 x upper limit of normal (ULN)

- Signed informed consent must be obtained prior to any study specific procedures

Exclusion Criteria:

- History of cardiac disease: congestive heart failure (CHF) > NYHA Class II; active
coronary artery disease, myocardial infarction within 6 months prior to study entry;
new onset angina within 3 months or unstable angina or cardiac arrhythmias requiring
anti-arrhythmic therapy (beta blockers or digoxin are permitted)

- Uncontrolled hypertension defined as systolic blood pressure > 150 mm Hg and/or
diastolic blood pressure > 90 mmHg, despite optimal medical management

- History of HIV infection or chronic hepatitis B or C

- Active clinically serious infections (> Grade 2 NCI Common Terminology Criteria for
Adverse Events v3.0)

- Symptomatic metastatic brain or meningeal tumors unless the patient is > 6 months
from definitive therapy, has no evidence of tumor growth on an imaging study within 2
weeks prior to study entry and is clinically stable with respect to the tumor at the
time of study entry. Patients with brain metastases must not be undergoing acute
steroid therapy or steroid taper (chronic steroid therapy is acceptable provided that
the dose is stable for one month prior to and following screening radiographic
studies)

- Substance abuse, medical, psychological or social conditions that may interfere with
the patient178s participation in the study or evaluation of the study results

- Radiotherapy to the target lesions within 3 weeks prior to Day 1, Cycle 1 (first dose
of study drug). (Palliative radiotherapy will be allowed). Radiotherapy to the
target lesions during study will be regarded as progressive disease

- Previous or concurrent cancer which is distinct in primary site or histology from the
cancer being evaluated in this study EXCEPT cervical carcinoma in situ, treated basal
cell carcinoma, superficial bladder tumors [Ta, Tis and T1] or any cancer curatively
treated > 3 years prior to study entry.