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Tracing the Path of the Plant Pigment Cyanidin-3-glucoside, Through the Human Body After Consumption


N/A
18 Years
45 Years
Not Enrolling
Male
Metabolism and Clearance of Cyanidin 3 Glucoside

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Trial Information

Tracing the Path of the Plant Pigment Cyanidin-3-glucoside, Through the Human Body After Consumption


Inclusion Criteria:



- Males

- 18-45 years old

- No allergies to fruits or vegetables containing anthocyanins or foods to be provided
on the study day

- Those agreeing to restrict dietary intake of rich sources of anthocyanins

- Those agreeing to comply with a biological sampling protocol and have cannula
inserted for the collection of blood samples on the study day

- Those agreeing to record their dietary intake over 3 days (1 weekend day and 2 week
days)

Exclusion Criteria:

- Those judged by the study clinical staff (to be appointed) to have biochemical and /
or haematological screening results which reflect compromised health or that may
affect the study analysis

- Participants with a body mass index of less than 18.5 or greater than 30

- Taking food / dietary supplements containing anthocyanins e.g. grape seed extract,
acai berry (unless prepared to cease intake during, and 7 days preceding the study)

- Parallel participation in another research project which involves dietary
intervention and/or sampling of biological fluids/material

- Smokers or those who have ceased smoking within 12 months.

- Habitual drinkers of more than 4 units* of alcohol per day or more than 21 units per
week (NHS guidelines). *A unit of alcohol is approximately equivalent to a half pint
of full strength beer or cider or a small glass of wine (100ml) or a single measure
(25ml) of spirits

- Having donated blood in the last month

Type of Study:

Interventional

Study Design:

Endpoint Classification: Pharmacokinetics Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Basic Science

Outcome Measure:

The outcome measure for this study is the measure of the total amount of the 'heavy' label (which was incorporated into the C3G) in the blood, urine, faeces and breath samples in the 48 hours following consumption.

Outcome Time Frame:

72 hours

Safety Issue:

No

Principal Investigator

Colin Kay, PhD

Investigator Role:

Principal Investigator

Investigator Affiliation:

University of East Anglia

Authority:

United Kingdom: Research Ethics Committee

Study ID:

BB/H004963/1

NCT ID:

NCT01106729

Start Date:

July 2011

Completion Date:

September 2011

Related Keywords:

  • Metabolism and Clearance of Cyanidin 3 Glucoside
  • Flavonoids
  • Anthocyanin
  • Cyanidin 3 glucoside
  • Acute feeding trial
  • Stable isotope
  • Metabolism
  • Clearance
  • Bioavailability
  • Pharmacokinetics

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