A Pilot Study to Evaluate Tumor Pseudoprogression With FLT-PET and MRI
If you are eligible to participate in this study you will have a pre-treatment FLT-PET scan
within 7 days before starting treatment with radiation and temozolomide.
Two intravenous catheters (IVs) will be placed for each scan. One IV will be used to inject
the FLT for the PET scan and the contrast agent for the MRI scan. The second IV will be
used to draw blood for research tests. The PET scan will take about 2 hours. The MRI scan
will take about 60-75 minutes. They will be done simultaneously.
About 4 weeks after you finish radiation therapy you will have a second FLT-PET scan and MRI
Allocation: Non-Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Diagnostic
Primary Outcome Measure
To determine if elevated FLT PET uptake 4 weeks after completion of chemoradiation is associated with early tumor growth rather than treatment effect in patients with newly diagnosed glioblastome treated with standard chemoradiation.
Elizabeth Gerstner, MD
Massachusetts General Hospital
United States: Institutional Review Board
|Massachusetts General Hospital||Boston, Massachusetts 02114-2617|