A Prospective Study of Radiofrequency Ablation Combined With Chemotherapy for Pulmonary Tumors
Percutaneous image-guided RFA is a minimally invasive technique used to treat solid tumours.
Because of its ability to produce large volumes of coagulation necrosis in a controlled
fashion, this technique has gained acceptance as a viable therapeutic option for
unresectable liver malignancies. Recently, RFA has been proposed as a viable option for the
treatment of pulmonary malignancies. Experimental studies in animal tumor models have
confirmed the effectiveness of RFA in the destruction of experimentally-induced pulmonary
malignancies. Pilot clinical investigations have suggested that the treatment can achieve
high proportions of tumor response. We designed a prospective clinical trial aimed at
assessing feasibility, safety and effectiveness of RFA combined with chemotherapy in the
treatment of lung malignancies.
Observational Model: Case-Only, Time Perspective: Prospective
Jianxing He, MD, FACS
Department of Cardiothoracic Surgery, the First Affiliated Hospital of Guangzhou Medical College
China: Food and Drug Administration