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Hearing Loss and Complaint in Patients With Head and Neck Cancer Treated With Radiotherapy

11 Years
84 Years
Not Enrolling
Hearing Loss

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Trial Information

Hearing Loss and Complaint in Patients With Head and Neck Cancer Treated With Radiotherapy

Inclusion Criteria:

- The group of exposed individuals

- had to be patients with disease-free survival interval of at least two years
subsequent to treatment for head and neck cancer

- radiotherapy alone or in combination, in which the auditory system was included in
the field of irradiation.

- The group of non-exposed individuals (control group)

- had to be patients who had not undergone oncological treatment that put their hearing
at risk

- age-matched (2 years). This group was formed by individuals who had had pelvic tumors
or skin tumors and who had only undergone local surgery to remove their tumors, and
by female volunteers from the hospital.

- All of these individuals were asked whether they would be willing to participate in a
study, without knowing in advance whether they had any previous hearing problems or

Exclusion Criteria:

- congenital hearing loss

- otological surgery

Type of Study:


Study Design:

Observational Model: Case Control, Time Perspective: Prospective

Outcome Measure:

The hearing loss was evaluated through conventional tone threshold audiometry and a questionaire of hearing handicap was applied to both groups (individuals exposed to radiotherapy and the control group).

Outcome Description:

We observed mild to moderate hearing losses at frequencies of 57.4% in right ears and 59.6% in left ears in the group exposed to radiotherapy and in the control group, 43.3% ofmild to moderate hearing loss in both ears.Severe or profound hearing losses or anacusis occurred at frequencies of 6.4% in right ears and 8.5% in left ears, versus only 1.4% in the control group.Furthermore, severe handicap was observed in 2.8% of the individuals in the control group, versus 19.1% in the group exposed to radiotherapy.

Outcome Time Frame:

patientes were evaluated two years after finished the treatement


Brazil: National Committee of Ethics in Research

Study ID:




Start Date:

January 2005

Completion Date:

July 2007

Related Keywords:

  • Hearing Loss
  • hearing loss
  • head and neck cancer
  • radiotherapy
  • hearing complaint
  • Hearing loss due to the exposure of radiotherapy
  • Hearing Loss
  • Deafness
  • Head and Neck Neoplasms