Radiofrequency Ablation Versus Laser Ablation for the Treatment of Small Hepatocellular Carcinoma: a Randomized Controlled Trial
Percutaneous ablation is a safe and effective therapy for cirrhotic patients with HCC when
resection or liver transplantation is not possible. Among the various percutaneous local
ablative therapies, radiofrequency ablation (RFA) has attracted the greatest interest
because of its effectiveness and safety for single HCC ≤ 5.0cm or ≤3 HCC nodules ≤3cm. Some
studies have shown that laser ablation (LA) may be as effective as RFA in the treatment of
HCC. However, RFA and LA are different techniques and, in different cases (for example: size
or site of HCC nodule), each of these procedures may have some advantages or disadvantages.
Therefore there is the need for a prospective randomized controlled study to compare RFA and
LA in patients with small HCC.
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
Complete ablation of the HCC nodule, defined as absence of contrast enhancement of the nodule at CT or MRI imaging
four weeks after treatment
Giovan Giuseppe Di Costanzo, MD
Liver Unit - Cardarelli Hospital - Via A Cardarelli 9 - 80131 Naples-Italy
Italy: Ethics Committee