Inclusion Criteria:

- 50 to 70 years

- For myelodysplasia other than CMML: patients can be included if they have at least
one of these criteria:

1. IPSSintermediate 1 and poor cytogenetics (complex, 3 or 7 abnormality);

2. thrombopenia < 20x10ex9/L:

3. IPSS intermediate 2 or high

- For CMML: patients can be included if they have at least one of these criteria:

1. 2 of these criteria: hyperleucocytosis > 10x10exp9/L, splenomegaly>18cm,
hemoglobin < 10gr/dl, platelet < 100x10ex9/L

2. IPSS intermediate 2 or high

Exclusion Criteria:

- Patient not eligible for transplantation (including patients without donor)because of
severe co-morbidity including:

- Renal failure with creatinine clearance < 30ml/min

- Cirrhosis or hepatic failure

- Respiratory disease with vital capacity < 30%

- Uncontrolled cardiac failure

- Uncontrolled neurological disease

- Poor performance status with karnofsky < or = 60%