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Partial Wave Spectroscopic Detection of Colon Cancer Risk

18 Years
Open (Enrolling)
Ulcerative Colitis, Colon Cancer

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Trial Information

Partial Wave Spectroscopic Detection of Colon Cancer Risk

The purpose of this study is to study samples of rectal mucosa (the moist lining of the
rectum) using a new light scattering technology, called partial wave spectroscopy (PWS)in
patients who will undergo a colonoscopy or a flexible sigmoidoscopy and have a history of
ulcerative colitis (UC). PWS has been recently developed to allow scientists to learn about
any changes to the cells that may indicate a risk of developing colon cancer. We believe
that the PWS test will more accurately detect the risk of colon cancer.

Inclusion Criteria:

- Patient must be 18 years old or older.

- Patient is already scheduled for a standard of care colonoscopy or flexible

- Patient has not received chemotherapy.

- History of ulcerative colitis.

Exclusion Criteria:

- Patient is unable to give informed consent..

- Patient has received chemo or radiation therapy within the past 3 months.

Type of Study:


Study Design:

Observational Model: Cohort, Time Perspective: Prospective

Outcome Measure:

Study samples of rectal mucosa (the moist lining of the rectum) using PWS.

Outcome Description:

Samples will be collected and then shipped to Northwestern University for analysis using PWS. This is to assess accuracy of detecting the risk for colon cancer.

Outcome Time Frame:

1 year

Safety Issue:


Principal Investigator

David T Rubin, MD

Investigator Role:

Principal Investigator

Investigator Affiliation:

University of Chicago


United States: Institutional Review Board

Study ID:




Start Date:

March 2010

Completion Date:

Related Keywords:

  • Ulcerative Colitis
  • Colon Cancer
  • Colonoscopy
  • Flexible Sigmoidoscopy
  • Colonic Neoplasms
  • Colitis
  • Colitis, Ulcerative
  • Ulcer



University of Chicago, DCAM Chicago, Illinois  60637