Determining Levels of [D10] Phenanthrene Tetraol in Smokers' Urine
Forty apparently healthy smokers and non smokers (20 male, 20 female) will be recruited by
advertising in the Twin Cities area. This will be done by the Tobacco Use Research Center.
They will be screened in a phone call, then invited to come in for an orientation session
at which consent will be obtained. Pregnant smokers will be excluded. They will visit the
clinic weekly for 2 months and once monthly for 4 months for a total of 6 months
At each visit they will drink 5 ml of 50:50 ethanol:water containing 10 ug
[D10]phenanthrene. They will then collect their 24h urine and return it to the clinic. The
urine will be analyzed for [D10]phenanthrene tetraol. The goal of the study is to determine
the longitudinal stability of the amount of [D10]phenanthrene-tetraol in urine.
Allocation: Randomized, Endpoint Classification: Pharmacokinetics Study, Intervention Model: Crossover Assignment, Masking: Open Label, Primary Purpose: Basic Science
Deuterated phenanthrene tetraol ([D10]PheT) assessed post dosing for smoked versus oral administration.
36 hours post dosing
Stephen S Hecht, Ph.D.
University of Minnesota Masonic Cancer Center
United States: Food and Drug Administration
|Tobacco Use Research Center||Minneapolis, Minnesota 55414|