Inclusion Criteria:

- Confirmed diagnosis of HCC according to the European Association for the Study of the
Liver criteria

- Known underlying HCC etiology specified by hepatitis B, hepatitis C, post alcoholic
cirrhosis, or other

- HCC lesion(s) which are not resectable and which are measurable by C-T scan

- Progression of or non-response of HCC lesions after treatments which are considered
best standard of care - surgical resection, radiofrequency ablation,
chemoembolization

- No cancer treatment or surgery within the prior 4 weeks, either chemotherapy,
targeted biologic or enzymes, either approved or investigational;

- Males or females from 18 to 75 years-old, inclusive;

- Ability and willingness to provide written informed consent;

- Karnofsky performance status of 80% or above and expected survival of more than 12
weeks; and,

- Negative urine pregnancy test, if female, and willingness to use an effective method
of contraception during the entire study period

- No cognitive impairment

- Ability to understand and read Chinese

Exclusion Criteria:

- Advancing liver failure indicated by uncontrolled ascites, pleural effusions,
encephalopathy, or a Child-Pugh score of C

- Significant hepatic, renal or bone marrow dysfunction indicated by total bilirubin
>40 µmol/L, evidence of bile duct obstruction, serum albumin <30 g/L, serum SGOT >5 x
upper limit of normal, ANC <1.0 x 10^9/L, platelets <100 x 10^9/L, or INR >2.0

- Significant cardiac or pulmonary disease defined by New York Heart Association (NYHA)
Class III or IV, VEF <50% by echo or MUGA, or a history of myocardial infarction
within the past 6 months, significant unstable arrhythmia or evidence of ischemia on
ECG

- Pregnant or nursing women. NOTE: Women of child-bearing potential and men must agree
to use adequate contraception (hormonal or barrier method of birth control or
abstinence) prior to study entry and for the duration of study participation. Should
a woman become pregnant or suspect she is pregnant while participating in this study,
she should inform her treating physician immediately.

- Significant active infection including HIV requiring oral or parenteral
anti-infective therapies;

- Use of investigational drug(s) within 4 weeks of enrollment; or,

- Prior treatment with arginine depleting agent.