Inclusion Criteria:

(main conditions)

- Female patients 18 to 75 years of age with metastatic breast cancer
histologically/cytologically confirmed not amenable to curative surgery or
radiotherapy and who have received at least two prior chemotherapy regimens including
anthracyclines,taxanes,antimetabolite and vinca-alkaloid and are no longer candidate
for these drugs,

- Karnofsky performance score of at least 70 %, adequate haematological, hepatic and
renal functions and ECG without clinically relevant abnormality.

Exclusion Criteria:

- Concurrent serious uncontrolled medical disorder,

- known or clinical evidence of brain metastases or leptomeningeal involvement,

- pulmonary lymphangitis or symptomatic pleural effusion or symptomatic ascites,

- history of second primary malignancy,

- HIV infection, preexisting neuropathy,

- pregnancy or breast feeding.