Inclusion Criteria:

- Histologically documented, incurable, locally advanced or metastatic solid tumors for
which standard therapy either does not exist or has proven ineffective or
intolerable.

- Evaluable or measurable disease

- Life expectancy >= 12 weeks

- Adequate hematologic and organ function within 14 days before initiation of GDC-0068

- Documented willingness to use an effective means of contraception (e.g., abstinence,
hormonal or double barrier method, surgically sterilized partner) for both men and
women while participating in the study

Exclusion Criteria:

- History of Type 1 or 2 diabetes mellitus requiring regular medication

- Grade > 2 hypercholesterolemia or hypertriglyceridemia

- Malabsorption syndrome or other condition that would interfere with enteral
absorption

- Leptomeningeal disease as the only manifestation of the current malignancy

- Known untreated malignancies of the brain or spinal cord, or treated brain metastases
that are not radiographically stable for >= 3 months