Genomics Evolution in Childhood Acute Lymphoblastic Leukemia
In order to know the genomic evolution of childhood acute lymphoblastic leukemia, we will
collect bone marrow (10c.c.) at diagnosis, remission and relapse. We will do the following
genes in addition to gene-chip including IKZF1,ETV6, EBF1, NR3C1, RAG1/G2, TCF3, BTLA,
PAX5,LEF1, ERG and VPREB1.We will study the gene dosages and degree of methylation. The
estimated patients numbers will be 300-400. Then we will correlate these data with
patients'age, white blood cell count at diagnosis, cytogenetic abnormalities, response to
the chemotherapy and prognosis.
Observational Model: Case-Only, Time Perspective: Retrospective
Dong-Tsamn Lin, M.D.
National Taiwan University Hospital,Taipei,Taiwan
Taiwan: Department of Health