First International Inter-Group Study for Nodular Lymphocyte-Predominant Hodgkin's Lymphoma in Children and Adolescents
- Determine the 5-year event-free survival of children or adolescents with stage IA or
IIA nodular lymphocyte-predominant Hodgkin lymphoma treated with surgery alone or with
cyclophosphamide, vinblastine, and prednisolone.
- Determine if this regimen results in a decrease in overall survival rates, in
significant upstaging at relapse, or increased rates of histological transformation in
- Group 1 (patients with stage IA disease only): Patients undergo surgical resection of
the involved lymph nodes. Patients who achieve complete resection then enter follow-up
(watch and wait); patients who do not achieve complete resection enters group 2
- Group 2 (patients with stage IIA disease or incompletely resected stage IA disease):
Patients receive cyclophosphamide, vinblastine, and prednisolone for 3 courses.
Patients with good response enter follow-up (watch and wait). Patients without a good
response are taken off protocol.
After completion of study treatment, patients are followed-up periodically.
Masking: Open Label, Primary Purpose: Treatment
Dieter Koerholz, MD