Improving the Population-Wide Effectiveness of U.S. Tobacco Cessation Quitlines
The study design is a fully crossed 2x2x2 factorial design that tested the effect of two
versus six weeks of nicotine replacement therapy (NRT), the effect of NRT monotherapy
(nicotine patch alone) versus NRT combination therapy (nicotine patch + oral NRT), and the
effect of cognitive medication adherence counseling (CMAC) versus no CMAC. A total of 987
smokers seeking cessation assistance from the Wisconsin Tobacco Quit Line (WTQL) were
randomly assigned to the eight (2x2x2) different conditions generated by the three
experimental factors. This design provides us with sufficient power to analyze each of our
three main effects listed above. We will also test for two- and three-way interactions, but
do not have sufficient data to make a priori assumptions about interaction effects.
Finally, we will conduct a cost-effectiveness analysis for each of the three interventions
to allow readers of this research to evaluate whether the additional costs of the
interventions yield sufficient gains to warrant implementing them broadly.
The only people eligible for this study are Wisconsin residents who contact the Wisconsin
Tobacco Quit Line for smoking cessation services.
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Factorial Assignment, Masking: Single Blind (Outcomes Assessor), Primary Purpose: Treatment
7-Day Point Prevalence Abstinence From Smoking by Intervention
Self-reported total abstinence from any tobacco use (even a single puff) for the seven days preceding the target follow-up day.
26 weeks after the target quit smoking date
Stevens S Smith, PhD
University of Wisconsin Center for Tobacco Research and Intervention, School of Medicine and Public Health
United States: Institutional Review Board
|Wisconsin Tobacco Quit Line (service provided by Free & Clear, Inc.)||Seattle, Washington 98104|
|University of Wisconsin Center for Tobacco Research and Intervention||Madison, Wisconsin 53711|