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Does Hounsfield Unit (HU) Predict the Detection of Cystic Renal Malignancy of Complicated Renal Cysts?

20 Years
80 Years
Not Enrolling
Kidney Neoplasm, Cysts, Carcinoma, Renal Cell

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Trial Information

Does Hounsfield Unit (HU) Predict the Detection of Cystic Renal Malignancy of Complicated Renal Cysts?

Even though there have been many trials and errors to enhance the diagnostic accuracy of CT
scans for complicated cysts, the trial to obtain the enhanced accuracy using CT scan would
be still valuable, when we consider its widespread use. A previous study demonstrated that
the enhancement of HU with intravenous administration of contrast material on CT scan by 15
HU would be "almost always indicative of a pathologic process although not always a
malignancy", another study showed the cut-off as 42 or 47 HU gap would be helpful in the
prediction of renal malignancy.

Inclusion Criteria:

- All patients who were diagnosed as renal cysts

- available serial follow-up data of CT scan

- all CT imaging included non-enhanced (NEP), corticomedullary (CMP), and early
excretory phase (EEP) scans. The scan delay times should range from 30 to 40 seconds
for CMP scans and from 120 to 180 seconds for EEP scans.

Exclusion Criteria:

- cases diagnosed by only US/MR

- no serial CT images

- cysts of autosomal dominant adult polycystic kidney disease

- cysts less than 1cm in diameter (difficult to evaluate accurately)

- follow-up period less than 1 yr in the patients who had no surgery

Type of Study:


Study Design:

Observational Model: Case Control, Time Perspective: Retrospective

Outcome Measure:

additional diagnostic criteria of CT to diagnose and predict the detection and recurrence of cystic RCC in the patients with complicated renal cysts

Outcome Description:

First, the primary outcomes is to determine cut-off values of maximal HU and the maximal gap of HU (HU of early excretory phase minus that of non-enhanced phase in CT scan)to predict the detection of renal malignancy. Some clinical factors (age, height, body weight, etc) were also included in the analysis. Second, the above-mentioned factors were included in the analysis of risk factors for recurrence of complicated renal cysts to determine the cut-off values.

Safety Issue:


Principal Investigator

Cheol Kwak, M.D.,Ph.D.

Investigator Role:

Principal Investigator

Investigator Affiliation:

Seoul National University Hospital


Korea: Institutional Review Board

Study ID:




Start Date:

January 1997

Completion Date:

May 2009

Related Keywords:

  • Kidney Neoplasm
  • Cysts
  • Carcinoma, Renal Cell
  • Neoplasms
  • Carcinoma
  • Carcinoma, Renal Cell
  • Cysts
  • Kidney Neoplasms