Acoustic Radiation Force Impulse Imaging (ARFI) : a New Technique to Assess Liver Elasticity - Norms in ARFI: Distribution and Reproducibility of ARFI Values in Disease-free Livers or Pathological Livers.
There are many causes of chronic liver diseases such as hepatitis C infection, hepatitis B
infection, alcohol, NAFLD (non-alcoholic fatty liver disease), drugs and auto-immune liver
Although the causes differ the pathological response to injury tends to be similar leading
to fibrosis and cirrhosis.
Liver biopsy is the current gold standard for the assessment of liver fibrosis but is poorly
suited for active monitoring because of its expense and morbidity. Thus, development of
alternatives that are safe, inexpensive, and reliable is a priority.
Liver stiffness measurement (LSM) by non invasive method is increasingly used to estimate
liver fibrosis in patient with chronic liver disease. Acoustic radiation force impulse
imaging (ARFI) is a new technology to perform real time LSM. Using a standard
ultrasonographic probe, it offers elastography with a flexible metering box at variable
depth, allowing the examination of specific area.
The purpose of this work was to evaluate by ARFI, the efficiency of this new technique, the
reproducibility inter and intra observer, and the liver elasticity obtained by this method
in different patient groups.
The primary endpoint of this work is to evaluate by ARFI, the efficiency of the technique,
the reproducibility inter and intra observer, and the elasticity of liver in 6 different
patient groups and healthy volunteers.
The different population groups are:
- healthy volunteers Group A
- patients with supposed disease free liver (normal hepatic and pancreatic biochemistry).
- patients with non cirrhotic hepatopathy. Group C
- patients with cirrhosis. Group D
- patients with liver tumour and surgery indication. Group E
- patients with reversible liver diseases:
- patients with acute left cardiac insufficiency. Group F
- patients with biliary cholestasis. Group G
ARFI measurements will be performed in a single liver ultrasound exam visit except for
patients with reversible liver diseases who will have a second visit with ARFI measurement
after clinical healing. The ARFI values are expressed as a speed in m/s.
Allocation: Non-Randomized, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Diagnostic
The elasticity parameter will be for each patient the median of ten ARFI values (m/s) in the right liver.
One or two 30 min visit according to the patient group
Nora FRULIO, Md MSc
University Hospital, Bordeaux
France: Afssaps - Agence française de sécurité sanitaire des produits de santé (Saint-Denis)